期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 37, 期 8, 页码 2987-3000出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X16681310
关键词
Cerebral blood flow; intravoxel incoherent motion; magnetic resonance imaging; microcirculation; perfusion
资金
- ANR [ANR-13-NEUC-0002-01]
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R01EB018107]
- Agence Nationale de la Recherche (ANR) [ANR-13-NEUC-0002] Funding Source: Agence Nationale de la Recherche (ANR)
IntraVoxel Incoherent Motion (IVIM) is a magnetic resonance imaging (MRI) technique capable of measuring perfusion-related parameters. In this manuscript, we show that the mono-exponential model commonly used to process IVIM data might be challenged, especially at short diffusion times. Eleven rat datasets were acquired at 7T using a diffusion-weighted pulsed gradient spin echo sequence with b-values ranging from 7 to 2500 s/mm(2) at three diffusion times. The IVIM signals, obtained by removing the diffusion component from the raw MR signal, were fitted to the standard mono-exponential model, a bi-exponential model and the Kennan model. The Akaike information criterion used to find the best model to fit the data demonstrates that, at short diffusion times, the bi-exponential IVIM model is most appropriate. The results obtained by comparing the experimental data to a dictionary of numerical simulations of the IVIM signal in microvascular networks support the hypothesis that such a bi-exponential behavior can be explained by considering the contribution of two vascular pools: capillaries and somewhat larger vessels.
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