期刊
MATERIALS TODAY BIO
卷 15, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mtbio.2022.100308
关键词
Coassembly; Cascade-responsive; Hyperglycemia; ROS-Scavenging; Diabetic wound
资金
- National Natural Science Foundation of China [81703156]
- Chongqing special project for technological innovation and application development [cstc2020jscx-msxmX0070]
- Youth Talent Foundation in College of Pharmacy, China
- Chongqing Medical University [YXY2019QNGD1]
This study developed a glucose/ROS cascade-responsive nanozyme for diabetic wound treatment, which effectively regulates the microenvironment and promotes wound healing. In vitro and in vivo experiments demonstrated its potential in diabetic wound repair.
Diabetic wounds have an extremely complex microenvironment of hyperglycemia, hypoxia and high reactive oxygen species (ROS). Therefore, the regulation and management of this microenvironment may provide a new and improved treatment method for chronic diabetic wound healing. Herein, a glucose/ROS cascade-responsive nanozyme (CHA@GOx) was developed for diabetic wound treatment based on Ce-driven coassembly by a special dual ligand (alendronic acid and 2-methylimidazole) and glucose oxidase (GOx). It possesses superoxide dismutase and catalase mimic activities, which effectively remove excess ROS. In particular, it can catalyze excessive hydrogen peroxide generated by the glucose oxidation reaction to produce oxygen, regulate the oxygen balance of the wound, and reduce the toxic side effects of GOx, thus achieving the purpose of synergistically repairing diabetic wounds. In vitro experiments show that CHA@GOx assists mouse fibroblast migration and promotes human umbilical vein endothelial cell tube formation. In vivo, it can induce angiogenesis, collagen deposition, and re-epithelialization during wound healing in diabetic mice. Taken together, this study indicates that the coassembly of multifunctional nanozymes has implications in diabetic wound healing.
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