期刊
MATERIALS TODAY NANO
卷 18, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mtnano.2022.100218
关键词
Nanoceria; Antioxidant; Oxidative stress; Ocular diseases; Drug delivery
资金
- National Key Research and Development Program of China [2020YFE0204400, 2018YFC1106104]
- National Natural Science Foundation of China [82070939, 22005265, 22105126, 81870641]
- Key Research and Development Project of Zhejiang Province [2020C03035]
- Zhejiang Provincial Natural Science Foundation of China [LBY21E030002]
- Natural Science Foundation of Shanghai [22ZR1433500]
- National Facility for Translational Medicine (Shanghai) [TMSK2021-205]
- Postdoctoral Science Foundation of China [2020TQ0261]
Nanoceria, a nanozyme with unique auto-regenerative antioxidant capacity, shows potential in managing oxidative stress-related ocular diseases and delivering drugs to ocular tissues. This review discusses recent advances and the importance of surface modification in enhancing the safety and targeting properties of nanoceria.
Nanoceria, well known as a type of nanozyme, exhibits unique auto-regenerative antioxidant capacity, mainly originating from a fraction of Ce3+ ions that can be reversibly switched to the Ce4+ ions in cerium oxide. This antioxidant nanoceria can potentially scavenge noxious reactive oxygen species, leading to its wide applications in the management of various oxidative stress-related diseases, especially ocular diseases. Besides, nanoceria could be adopted as a nanocarrier to deliver specific drug to ocular tissues. This review would give a detailed introduction on the recent exciting advances of nanoceria application in various preclinical ophthalmic disease models, including corneal diseases, lens diseases, glaucoma, and retinal diseases. And ease of surface modification would help improving the safety, bioavailability, and ocular targeting properties of nanoceria, making nanoceria a versatile and promising nanomaterial for biomedical applications in the future. (C) 2022 Elsevier Ltd. All rights reserved.
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