4.4 Article

Altered large-scale brain network interactions associated with HIV infection and error processing

期刊

NETWORK NEUROSCIENCE
卷 6, 期 3, 页码 791-815

出版社

MIT PRESS
DOI: 10.1162/netn_a_00241

关键词

HIV; Resting-state functional connectivity; Error awareness; Cannabis; Default mode network; Central executive network; Salience network

资金

  1. Foundation for the National Institutes of Health [R01DA041353, K01DA037819, R01DA033156, U54MD012393]
  2. National Science Foundation [1631325]
  3. Div Of Information & Intelligent Systems
  4. Direct For Computer & Info Scie & Enginr [1631325] Funding Source: National Science Foundation

向作者/读者索取更多资源

This study investigated the impact of HIV and cannabis on brain network connectivity. The findings suggest that HIV-positive individuals showed reduced connectivity in certain brain networks, which may affect error processing.
Altered activity within and between large-scale brain networks has been implicated across various neuropsychiatric conditions. However, patterns of network dysregulation associated with human immunodeficiency virus (HIV), and further impacted by cannabis (CB) use, remain to be delineated. We examined the impact of HIV and CB on resting-state functional connectivity (rsFC) between brain networks and associations with error awareness and error-related network responsivity. Participants (N = 106), stratified into four groups (HIV+/CB+, HIV+/CB-, HIV-/CB+, HIV-/CB-), underwent fMRI scanning while completing a resting-state scan and a modified Go/NoGo paradigm assessing brain responsivity to errors and explicit error awareness. We examined separate and interactive effects of HIV and CB on resource allocation indexes (RAIs), a measure quantifying rsFC strength between the default mode network (DMN), central executive network (CEN), and salience network (SN). We observed reduced RAIs among HIV+ (vs. HIV-) participants, which was driven by increased SN-DMN rsFC. No group differences were detected for SN-CEN rsFC. Increased SN-DMN rsFC correlated with diminished error awareness, but not with error-related network responsivity. These outcomes highlight altered network interactions among participants with HIV and suggest such rsFC dysregulation may persist during task performance, reflecting an inability to disengage irrelevant mental operations, ultimately hindering error processing.

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