期刊
INTERNATIONAL JOURNAL OF BIOPRINTING
卷 8, 期 2, 页码 80-94出版社
WHIOCE PUBL PTE LTD
DOI: 10.18063/ijb.v8i2.543
关键词
Bioresorbable stent; Nanofiber; Dipyridamole; Anti-restenosis; Endothelialization
资金
- Tsinghua University Initiative Scientific Research Program [20197050024]
- 111 Project [B17026]
The study proposed an integrated bioresorbable stent coated with dipyridamole-loaded nanofibers, which effectively prevents the proliferation of smooth muscle cells without adverse effects on endothelial cells, and exhibits excellent hemocompatibility. The in vivo implantation of the stent showed initial patency and continuous endothelialization, alleviating neointimal formation, indicating its potential for restenosis prevention and endothelialization.
Intimal hyperplasia and restenosis caused by excessive proliferation of smooth muscle cells (SMC) are the main factors for the failure of stent implantation. Drug-eluting stents carried with antiproliferative drugs have emerged as a successful approach to alleviate early neointimal development. However, these agents have been reported to have an undesirable effect on re-endothelialization. In this study, we proposed an integrated bioresorbable stent coated with dipyridamole (DP) loaded poly(D,L-lactide) (PDLLA) nanofibers. Three-dimensional (3D) bioresorbable stents were fabricated by printing on a rotation mandrel using polycaprolactone (PCL), and the stents were further coated with PDLLA/DP nanofibers. The in vitro degradation and drug release evaluation illustrated the potential for long-term release of DP. Stents coated with PDLLA/DP nanofibers showed excellent hemocompatibility. The cell viability, proliferation, and morphology analysis results revealed that stents coated with PDLLA/DP nanofibers could prevent the proliferation of SMC and have no adverse effects on endothelial cells. The in vivo implantation of stents coated with PDLLA/DP nanofibers showed initial patency and continuous endothelialization and alleviated neointimal formation. The attractive in vitro and in vivo performance indicated its potential for restenosis prevention and endothelialization.
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