期刊
NEUROLOGY AND THERAPY
卷 11, 期 3, 页码 981-1042出版社
SPRINGER LONDON LTD
DOI: 10.1007/s40120-022-00363-7
关键词
Neuroprotection; Multiple sclerosis; Progressive form; Statins; BTKi; Antioxidant
Multiple sclerosis is a chronic inflammatory disease with no neuroprotective drugs available. Research has identified potential targets for protecting axons from degeneration, offering hope for patients.
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) resulting in demyelination and neurodegeneration. The therapeutic strategy is now largely based on reducing inflammation with immunosuppressive drugs. Unfortunately, when disease progression is observed, no drug offers neuroprotection apart from its anti-inflammatory effect. In this review, we explore current knowledge on the assessment of neurodegeneration in MS and look at putative targets that might prove useful in protecting the axon from degeneration. Among them, Bruton's tyrosine kinase inhibitors, anti-apoptotic and antioxidant agents, sex hormones, statins, channel blockers, growth factors, and molecules preventing glutamate excitotoxicity have already been studied. Some of them have reached phase III clinical trials and carry a great message of hope for our patients with MS.
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