期刊
LUPUS SCIENCE & MEDICINE
卷 9, 期 1, 页码 -出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/lupus-2021-000607
关键词
autoimmunity; systemic lupus erythematosus; disease activity
类别
资金
- Swedish Research Council [2012-02480, 2012-07110, 2014-33867]
- Center for Innovative Medicine (CIMED) [FoUI-954540]
- Region Stockholm [FoUI-954341]
- Swedish Heart-Lung Foundation [20130430, 20130552, 20170257]
- Stockholm County Council [2014016, 20170038]
- Swedish Society of Medicine
- Ingegerd Johansson's Foundation [SLS-713911]
- King Gustaf V 80th Birthday Fund [FAI-2017-0390]
- Swedish Rheumatism Association [R-739631]
- Karolinska Institutet's Foundations
- Swedish Dental Society
- Sormland county [DLL-614351, DLL-648991]
- Folktandvarden Stockholms Lan AB, Sweden
- Swedish Research Council [2012-07110, 2012-02480] Funding Source: Swedish Research Council
This study found that saliva could be a novel alternative body fluid for monitoring general disease activity (DA) in patients with SLE, while urine is more informative for SLE patients with predominantly renal DA.
Background Laboratory tests of blood and sometimes urine are used to diagnose and to monitor disease activity (DA) in SLE. Clinical practice would be simplified if non-invasive urine and salivary tests could be introduced as alternatives to blood samples. We therefore explored the levels of innate immunity-related biomarkers in matched serum, urine and saliva samples from patients with SLE. Methods A total of 84 patients with SLE selected to represent high and low general DA, and 21 controls were included. All participants underwent a thorough clinical examination. General DA and renal DA were measured. The levels of colony-stimulating factor (CSF)-1, interleukin (IL)-34, tumour necrosis factor (TNF)-alpha, interferon-gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, calprotectin, macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta were analysed by immunoassays and related to DA. Results CSF-1, TNF-alpha, IP-10 and MCP-1 in saliva, serum and urine, as well as calprotectin in saliva and urine were increased in patients with SLE as compared with controls (p<0.05). TNF-alpha, IP-10 and MCP-1 in saliva, serum and urine, and CSF-1 in saliva and serum distinguished patients with SLE from controls (area under the curve >0.659; p<0.05 for all). CSF-1 in serum and urine, and calprotectin in saliva and urine, as well as TNF- alpha, IP-10 and MCP-1 in urine correlated positively with measures of general DA (p<0.05). Patients with SLE with active renal disease presented elevated levels of TNF-alpha, IP-10 and MCP-1 in urine and CSF-1 and IP-10 in serum as compared with patients with SLE with non-active renal disease. Conclusions Our investigation demonstrates that saliva is a novel alternative body fluid, with potential for surveillance of general DA in patients with SLE, but urine is more informative in patients with SLE with predominantly renal DA.
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