Factors associated with poor antibody response to third-dose SARS-CoV-2 vaccination in patients with rheumatic and musculoskeletal diseases

Article Medicine, General & Internal

Association of a Third Dose of BNT162b2 Vaccine With Incidence of SARS-CoV-2 Infection Among Health Care Workers in Israel

Avishay Spitzer et al.

Summary: A booster dose of BNT162b2 vaccine was associated with a significantly lower risk of SARS-CoV-2 infection among health care workers who were previously vaccinated with a 2-dose series of the same vaccine. The study was conducted in Israel and included 1928 participants with a median follow-up of 39 days.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Multidisciplinary Sciences

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

Peter B. Gilbert et al.

Summary: In the COVE phase 3 clinical trial, neutralizing and binding antibodies were measured in vaccine recipients to determine their correlation with COVID-19 risk and vaccine efficacy. The results showed that these immune markers were inversely associated with COVID-19 risk and directly associated with vaccine efficacy. Postvaccination neutralization titers of 10, 100, and 1000 correlated with estimated vaccine efficacies of 78%, 91%, and 96% respectively.

SCIENCE (2022)

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Editorial Material Rheumatology

Antibody durability 6 months after two doses of SARS-CoV-2 mRNA vaccines in patients with rheumatic and musculoskeletal disease

Sarah Frey et al.

LANCET RHEUMATOLOGY (2022)

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Letter Rheumatology

Booster-dose SARS-CoV-2 vaccination in patients with autoimmune disease: a case series

Caoilfhionn M. Connolly et al.

ANNALS OF THE RHEUMATIC DISEASES (2022)

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Article Microbiology

Quantitative Measurement of Anti-SARS-CoV-2 Antibodies: Analytical and Clinical Evaluation

Victoria Higgins et al.

Summary: A study evaluating the quantitative Roche Elecsys anti-SARS-CoV-2 S assay showed high sensitivity, specificity, and positive predictive value in detecting SARS-CoV-2 antibodies post-infection. The study also demonstrated the assay's highest sensitivity at 15 to 30 days post-KR positivity and varying negative predictive values at different time points post-PCR positivity.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

Shuo Feng et al.

Summary: Defined levels of SARS-CoV-2-specific binding and neutralizing antibodies elicited by the COVID-19 vaccine were identified as correlates of protection against symptomatic infection. Higher levels of immune markers were correlated with a reduced risk of symptomatic infection. The data can be used to extrapolate efficacy estimates to new populations.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 A Prospective Cohort Study

Parakkal Deepak et al.

Summary: Patients with CID show immune response to mRNA-based SARS-CoV-2 vaccines, but some may have lower antibody levels, especially those receiving glucocorticoids and B-cell depletion therapy. Further studies are needed to confirm these preliminary findings.

ANNALS OF INTERNAL MEDICINE (2021)

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Letter Medicine, General & Internal

Absence of Humoral Response After Two-Dose SARS-CoV-2 Messenger RNA Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: A Case Series

Caoilfhionn M. Connolly et al.

ANNALS OF INTERNAL MEDICINE (2021)

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Factors associated with poor antibody response to third-dose SARS-CoV-2 vaccination in patients with rheumatic and musculoskeletal diseases

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