期刊
ACS APPLIED POLYMER MATERIALS
卷 4, 期 6, 页码 4576-4587出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsapm.2c00585
关键词
electrospinning; core-sheath nanofiber; antibacterial photodynamic therapy; zwitterionic polymer; polyurethane
资金
- Ministry of Science and Technology of Taiwan [MOST 109-2221-E-194-045]
This study developed an antibacterial wound dressing using coaxial electrospinning technology. The dressing showed good biocompatibility, antifouling performance, and had the potential to be used for wound healing and infection prevention.
Skin wounds and their related bacterial infections are one of the issues that would seriously threaten public health. Wound dressings affording antibiofouling capability and incorporating antimicrobial agents could prevent infection and favor wound healing, which have significant clinical demands and value. Antibacterial photodynamic therapy (aPDT) induces toxic singlet oxygen to kill microbes through a photodynamic pathway that avoid the development of drug-resistant microbes. In this study, coaxial electrospinning technology was employed to fabricate an antibacterial wound dressing containing thermoplastic polyurethane (TPU) as the core and zwitterionic and cross-linkable polysulfobetaine copolymer as the sheath. The prepared nanofibrous membranes exhibited good water uptake and retention capability, excellent in vitro biocompatibility and antifouling performance. The elastic properties of TPU improved the stretching and mechanical performance of the membranes that mimic the extensibility of the human skin. Moreover, methylene blue-loaded nanofibrous membranes have shown good antibacterial photodynamic inactivation against Gram-positiveStaphylococcus aureus (99.875%, 2.90 log units inactivation) and Gram-negative Escherichia toll (99.705%, 2.53 log units inactivation) upon mild light irradiation (500 W m(-2)), while as expected, E. coli cells have shown lower susceptibility to aPDT. Overall, the zwitterionic core-sheath nanofibrous membranes with aPDT function are potentially used as a promising antibacterial wound dre ss ing.
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