期刊
ACS APPLIED NANO MATERIALS
卷 5, 期 5, 页码 6089-6093出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.2c01226
关键词
peroxidase mimics; iridium nanoparticle; particle size; catalysis; bioassay
资金
- National Science Foundation [CBET-1804525, CHE1834874]
- University of Central Florida (UCF)
This study reports a peroxidase mimic composed of iridium nanoparticles coupled to a tungsten suboxide nanorod. The peroxidase mimic has a high catalytic efficiency and can be used for colorimetric immunoassays with substantially enhanced detection sensitivity.
In this work, we report a peroxidase mimic composed of iridium (Ir) nanoparticles with an average size of only 1.1 nm that are coupled to a tungsten suboxide (WO2.72) nanorod as support. Such a peroxidase mimic exhibited an area-specific catalytic efficiency as high as 1.5 x 10(4) s(-1) nm(-2), outperforming most existing peroxidase mimics of noble metals. As proof-of-concept demonstrations, the peroxidase mimic was applied to colorimetric immunoassays of carcinoembryonic antigen (a cancer biomarker) and aflatoxin B1 (a potent carcinogen), which provided substantially enhanced detection sensitivities compared to conventional enzyme-based assays.
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