期刊
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
卷 15, 期 -, 页码 3133-3142出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJGM.S350448
关键词
gastric cancer; signet ring cell carcinoma; long-time survivor; nomogram
资金
- Science and Technology Research on Public Welfare Project of Ningbo, Zhejiang Province [2021S178]
- Ningbo Nature Fund Project [2021J253]
- Zhejiang Province Public Welfare Technology Application Research Project of China [LGF22H160039]
This study analyzed the clinicopathological characteristics of long-term survivors with non-metastatic gastric signet ring cell carcinoma and identified independent predictors of long-term survival. Age, race, sex, marital status, tumor size, tumor infiltration, and lymph node involvement were found to be significant factors in predicting long-term survival.
Objective: Gastric signet ring cell carcinoma (SRCC) is a distinct entity with a relatively poor prognosis. This study analyzed the clinicopathological characteristics of long-time survivors (LTSs) and identified independent predictors of long-term survival (LTS) in non-metastatic gastric SRCC. Methods: Data from 3906 patients with non-metastatic gastric SRCC were retrieved from Surveillance, Epidemiology and End Results according to the inclusion and exclusion criteria. Patients were randomly divided into training and validation cohorts. Predictors of LTS in the training cohort were identified by multivariate logistic regression. A nomogram-based predictive model for LTS was constructed in non-metastatic gastric SRCC. Results: There were 800 patients who survived for >5 years and were defined as TLSs. Young age, other race (not black or white population), female gender, married status, small tumor size, low tumor infiltration, and negative lymph node involvement were independent predictors of LTS in non-metastatic gastric SRCC. These seven variables were incorporated into a nomogram model for predicting LTS. The calibration curve showed good consistency between observed and predicted probability of LTS, and the receiver operating characteristic curve showed acceptable discriminative capacity in the training and validation cohorts. Conclusion: This study provides an overview of the features of patients with non-metastatic gastric SRCC. Age, race, sex, marital status, tumor size, tumor infiltration, and lymph node involvement were identified as independent predictors of LTS.
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