期刊
JOURNAL OF CELL SCIENCE
卷 129, 期 13, 页码 2651-2659出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.189076
关键词
Drosophila; Epithelia; Polarity; Microtubules; Microvilli; Spectrin
类别
资金
- Francis Crick Institute
- Wellcome Trust [GA3404]
- The Francis Crick Institute [10180] Funding Source: researchfish
- Wellcome Trust [102853/B/13/Z] Funding Source: researchfish
In epithelial tissues, polarisation of microtubules and actin microvilli occurs along the apical-basal axis of each cell, yet how these cytoskeletal polarisation events are coordinated remains unclear. Here, we examine the hierarchy of events during cytoskeletal polarisation in Drosophila melanogaster epithelia. Core apical-basal polarity determinants polarise the spectrin cytoskeleton to recruit the microtubule-binding proteins Patronin (CAMSAP1, CAMSAP2 and CAMPSAP3 in humans) and Shortstop [Shot; MACF1 and BPAG1 (also known as DST) in humans] to the apical membrane domain. Patronin and Shot then act to polarise microtubules along the apical-basal axis to enable apical transport of Rab11 endosomes by the Nuf-Dynein microtubule motor complex. Finally, Rab11 endosomes are transferred to the MyoV (also known as Didum in Drosophila) actin motor to deliver the key microvillar determinant Cadherin 99C to the apical membrane to organise the biogenesis of actin microvilli.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据