期刊
PHOTONICS
卷 9, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/photonics9030158
关键词
glaucoma; altitude; intraocular pressure; mathematical modeling; physiology-enhanced data analytics
类别
资金
- NIH [R01EY030851]
- NSF [DMS 1853222/2021192, DMS 2108711/2108665]
- Research to Prevent Blindness, NY
Altitude has an impact on intraocular pressure, blood pressure, and retinal hemodynamics. The study found that increasing altitude leads to an increase in blood flow and pressure in the retinal vasculature, while decreasing intraocular pressure. These findings provide insights into the underlying mechanisms of changes in ocular blood flow and pressure at different altitudes.
Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (pe) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. Pe retinal hemodynamics analysis predicted a statistically significant increase (p < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (p < 0.001) and retinal venules (p = 0.003) and a non-significant increase in the resistance in the central retinal vein (p = 0.253). Pe aqueous humor analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据