期刊
JOURNAL OF CELL SCIENCE
卷 129, 期 12, 页码 2289-2295出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.183319
关键词
CYLD; Microtubule; Cell migration; Cell cycle; Drug sensitivity; Ciliogenesis
类别
资金
- National Natural Science Foundation of China [31471262, 31130015, 30825022, 30600313]
- National Basic Research Program of China [2012CB945002, 2010CB912204]
Microtubules are dynamic structures that are crucially involved in a variety of cellular activities. The dynamic properties and functions of microtubules are regulated by various factors, such as tubulin isotype composition and microtubule-binding proteins. Initially identified as a deubiquitylase with tumor-suppressing functions, the protein cylindromatosis (CYLD) has recently been revealed to interact with microtubules, modulate microtubule dynamics, and participate in the regulation of cell migration, cell cycle progression, chemotherapeutic drug sensitivity and ciliogenesis. These findings have greatly enriched our understanding of the roles of CYLD in physiological and pathological conditions. Here, we focus on recent literature that shows how CYLD impacts on microtubule properties and functions in various biological processes, and discuss the challenges we face when interpreting results obtained from different experimental systems.
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