期刊
FOOD SCIENCE AND HUMAN WELLNESS
卷 11, 期 3, 页码 635-642出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.fshw.2021.12.020
关键词
Oolong tea; Selenium; Anti-inflammatory; NF-kappa B and MAPK pathways
资金
- Fujian Special Research Projects for Public Scientific Research Institutions [2020R1032001]
The study investigated the anti-inflammatory effects of selenium-enriched oolong tea extract (Se-TE) on lipopolysaccharide-induced macrophages. The results showed that Se-TE significantly suppressed the overproduction of nitric oxide and prostaglandin E2, as well as inhibited the production of inflammatory cytokines. The underlying mechanism involved the blocking of mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways.
Both tea polyphenols and selenium (Se) have been suggested to exert the health benefits via the regulatory capacities of chronic inflammation, which make Se-enriched oolong tea a promising beverage as an anti-inflammatory diet. The aim of this study is to investigate the anti-inflammatory effects of Se-enriched oolong tea extract (Se-TE) and underlying mechanism in lipopolysaccharide (LPS)-induced RAW264.7 cells. Se-TE treatments (50 and 150 mu g/mL) significantly suppressed the over-production of nitric oxide (NO) and prostaglandin E2 (PGE(2)) in LPS-stimulated macrophages via downregulating the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, Se-TEs also effectively inhibited the productions of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta). Furthermore, Se-TE could block mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappa B) signaling pathways through the inhibition of the phosphorylation of key proteins (I kappa B-alpha, p65, p38, ERK, and JNK) and the translocation of the p65 subunit into the nucleus. Collectively, our results indicated that Se-TE may have the potential to be used as a novel food ingredient for the development of various anti-inflammatory foods and the treatment and prevention of chronic inflammation-related diseases. (C) 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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