期刊
LIFE-BASEL
卷 12, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/life12060794
关键词
obesity; pregnancy; rat; adipokines; cytokines; sex hormones; uterine contractility; cervical resistance
资金
- RECOOP-Cedars-Sinai Senior Scientists Grant [03/2018]
This study investigates the effects of obesity on pregnant uterine contraction in a rat model and finds that obesity reduces uterine contractility and cytokine-induced inflammatory processes, demonstrating partial applicability of obese pregnant rats as a model for human processes.
Background: In obesity, the adipose tissue becomes a very significant endocrine organ producing different factors called adipokines, such as leptin, adiponectin and kisspeptin; however, no data are available about their actions on uterine contraction in obese pregnant rats. Our aim was to study the impact of obesity on pregnant uterine contraction in a rat model. Methods: Obesity was induced by the consumption of a high fat high sucrose diet (HFHSD) for 9 weeks, including pregnancy. Glucose tolerance, sex hormone, cytokine and adipokine levels were measured. Uterine contractions and cervical resistance, as well as their responses to adipokines, were tested along with the expressions of their uterine receptors. Results: HFHSD increased body weight, and altered glucose tolerance and fat composition. The uterine leptin and kisspeptin pathway affect increased. The levels of proinflammatory cytokines were reduced, while the plasma level of progesterone was increased, resulting in weaker uterine contractions, and improving the uterine relaxing effects of adipokines. HFHSD reduced cervical resistance, but the core effect of adipokines is difficult to determine. Conclusions: Obesity in pregnant rats reduces uterine contractility and cytokine-induced inflammatory processes, and therefore obese pregnant rat methods are partially applicable for modelling human processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据