期刊
JOURNAL OF CELL SCIENCE
卷 129, 期 16, 页码 3059-3066出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.188920
关键词
Autophagy; Lysosome; Transcription
类别
资金
- FEBS Long-Term fellowship
- La Ligue Contre Le Cancer
- Korea-UK Collaborative Alzheimer's disease Research Project by Ministry of Health & Welfare, Republic of Korea [HI14C1913]
- Wellcome Trust Principal Research Fellowship [095317/Z/11/Z]
- Wellcome Trust Strategic Grant [100140/Z/12/Z]
- Korea Health Promotion Institute [HI14C1913030015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Wellcome Trust [100140/Z/12/Z] Funding Source: Wellcome Trust
Macroautophagy, hereafter referred to as autophagy, is a catabolic process that results in the lysosomal degradation of cytoplasmic contents ranging from abnormal proteins to damaged cell organelles. It is activated under diverse conditions, including nutrient deprivation and hypoxia. During autophagy, members of the core autophagy-related (ATG) family of proteins mediate membrane rearrangements, which lead to the engulfment and degradation of cytoplasmic cargo. Recently, the nuclear regulation of autophagy, especially by transcription factors and histone modifiers, has gained increased attention. These factors are not only involved in rapid responses to autophagic stimuli, but also regulate the long-term outcome of autophagy. Now there are more than 20 transcription factors that have been shown to be linked to the autophagic process. However, their interplay and timing appear enigmatic as several have been individually shown to act as major regulators of autophagy. This Cell Science at a Glance article and the accompanying poster highlights the main cellular regulators of transcription involved in mammalian autophagy and their target genes.
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