期刊
LIFE-BASEL
卷 12, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/life12060803
关键词
vascular aging; arterial stiffness; SGLT2 inhibitors; early vascular aging; diabetes mellitus; cardiovascular risks
Vascular aging is closely related to the occurrence of cardiovascular diseases. Sodium-glucose cotransporter 2 inhibitors can reduce arterial stiffness and vascular resistance, improve endothelial function, and decrease the risk of cardiovascular events.
Vascular aging, early vascular aging or supernormal vascular aging are concepts used for estimating the cardiovascular risk at a certain age. From the famous line of Thomas Sydenham that a man is as old as his arteries to the present day, clinical studies in the field of molecular biology of the vasculature have demonstrated the active role of vascular endothelium in the onset of cardiovascular diseases. Arterial stiffness is an important cardiovascular risk factor associated with the occurrence of cardiovascular events and a high risk of morbidity and mortality, especially in the presence of diabetes. Sodium-glucose cotransporter 2 inhibitors decrease arterial stiffness and vascular resistance by decreasing endothelial cell activation, stimulating direct vasorelaxation and ameliorating endothelial dysfunction or expression of pro-atherogenic cells and molecules.
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