期刊
MEMBRANES
卷 12, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/membranes12030324
关键词
extracellular; vesicles; osteoporosis
类别
资金
- Shenzhen Key Medical Subject [SZXK023]
- Shenzhen San-Ming Project of Medicine [SZSM201612092]
- National Natural Science Foundation of China [82001319]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011290, 2019A1515110983]
- Bethune Charitable Foundation
- CSPC Osteoporosis Research Foundation Project [G-X-2020-1107-21]
- Shenzhen Scientific Research Project of Health and Family Planning System [SZXJ2018077]
Osteoporosis is a common metabolic bone disease characterized by high incidence rates. Extracellular vesicles (EVs) play a significant role in the pathogenesis of osteoporosis, and understanding their role can provide valuable insights for the prevention and treatment of osteoporosis.
As an insidious metabolic bone disease, osteoporosis plagues the world, with high incidence rates. Patients with osteoporosis are prone to falls and becoming disabled, and their cone fractures and hip fractures are very serious, so the diagnosis and treatment of osteoporosis is very urgent. Extracellular vesicles (EVs) are particles secreted from cells to the outside of the cell and they are wrapped in a bilayer of phospholipids. According to the size of the particles, they can be divided into three categories, namely exosomes, microvesicles, and apoptotic bodies. The diameter of exosomes is 30-150 nm, the diameter of microvesicles is 100-1000 nm, and the diameter of apoptotic bodies is about 50-5000 nm. EVs play an important role in various biological process and diseases including osteoporosis. In this review, the role of EVs in osteoporosis is systematically reviewed and some insights for the prevention and treatment of osteoporosis are provided.
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