期刊
JOURNAL OF CELL BIOLOGY
卷 215, 期 1, 页码 15-25出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201603076
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资金
- National Institutes of Health [DK091618, EY016807, K08 DK102902]
- Leona M. and Harry B. Helmsley Charitable Trust [2012-PG-MED002]
- Glenn Foundation for Medical Research
- American Federation for Aging Research [M14322]
- American Diabetes Association mentor-based Postdoctoral Fellowship [7-12-MN-64]
- American Association for the Study of Liver Diseases Emerging Liver Scholars Award
Circadian clocks are cell-autonomous timing mechanisms that organize cell functions in a 24-h periodicity. In mammals, the main circadian oscillator consists of transcription translation feedback loops composed of transcriptional regulators, enzymes, and scaffolds that generate and sustain daily oscillations of their own transcript and protein levels. The clock components and their targets impart rhythmic functions to many gene products through transcriptional, posttranscriptional, translational, and posttranslational mechanisms. This, in turn, temporally coordinates many signaling pathways, metabolic activity, organelles' structure and functions, as well as the cell cycle and the tissue-specific functions of differentiated cells. When the functions of these circadian oscillators are disrupted by age, environment, or genetic mutation, the temporal coordination of cellular functions is lost, reducing organismal health and fitness.
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