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How Surface-Enhanced Raman Spectroscopy Could Contribute to Medical Diagnoses

CHEMOSENSORS (2022)

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Article Chemistry, Analytical

A SERS aptasensor based on porous Au-NC nanoballoons for Staphylococcus aureus detection

Beibei Xie et al.

Summary: This work presents a new method for fabricating Au-NC-NBs with a large specific surface area and high N and Au content, which are used to develop a SERS aptasensor with wider linear range and better selectivity for detecting bacteria. The sensor also performs well in detecting bacteria in real food and biological samples, showing great potential in food safety monitoring and clinical diagnosis.

ANALYTICA CHIMICA ACTA (2022)

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Article Chemistry, Analytical

Highly sensitive surface-enhanced Raman scattering-based immunosensor incorporating half antibody-fragment for quantitative detection of Alzheimer's disease biomarker in blood

Su Ji Yang et al.

Summary: This study developed a sensor based on surface-enhanced Raman scattering (SERS) for the quantitative determination of tau protein in the plasma of AD patients. The sensor demonstrated ultra-sensitivity and specificity, enabling accurate detection of AD biomarkers and simple point-of-care testing in clinical diagnosis.

ANALYTICA CHIMICA ACTA (2022)

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Article Biochemical Research Methods

Quantitative detection of 6-thioguanine in body fluids based on a free-standing liquid membrane SERS substrate

Wen Liu et al.

Summary: A highly reproducible FLM SERS substrate was developed for quantitative detection of 6-TG in human urine and serum, with an optimized Au/Ag ratio of AgcoreAushell NPs. The platform showed stable experimental results with RSD below 10% and a calibration curve with an R-2 value of 0.988 in the range of 10-100 μg kg-1. The LOD of 6-TG was determined to be 5 μg kg-1, making it suitable for rapid and reliable analysis in body fluids.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022)

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Article Biochemical Research Methods

DNA-Gold Nanoparticle Conjugates for Intracellular miRNA Detection Using Surface-Enhanced Raman Spectroscopy

Won-Jun Lee et al.

Summary: A highly sensitive detection method based on surface-enhanced Raman spectroscopy (SERS) was reported for intracellular detection of micro RNAs (miRNAs) expression at the single-cell level. The method utilized conjugated nanoparticles to achieve miRNA detection, enabling the detection of low expression levels of miRNA and was validated in breast cancer cells.

BIOCHIP JOURNAL (2022)

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Article Biophysics

Self-assembled plasmonic nanoarrays for enhanced bacterial identification and discrimination

Tongtong Tian et al.

Summary: This study presents the development of highly efficient nanoparticle arrays for simultaneous capture, identification, and differentiation of bacteria using SERS technology, allowing for single-cell analysis of multiple bacterial species. The technology demonstrates high sensitivity, good reproducibility, and stability, with great potential in bacterial detection and phenotyping studies.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

Highly accurate and label-free discrimination of single cancer cell using a plasmonic oxide-based nanoprobe

Bao Yue Zhang et al.

Summary: A dual-functional nanoprobe based on dopant-driven plasmonic oxides is reported, which can accurately distinguish cancer cells at the single-cell level. This nanoprobe can differentiate different cells based on their SERS patterns and also enable colorimetric cell detection through bio-redox response.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

Acoustofluidic multimodal diagnostic system for Alzheimer's disease

Nanjing Hao et al.

Summary: Alzheimer's disease is a severe neurodegenerative disorder with early diagnosis being a challenge. Researchers have developed an integrated diagnostic system combining acoustics, microfluidics, and biosensors for accurate and rapid detection of AD biomarkers, showing promising results for early diagnosis.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

SERS-PCR assays of SARS-CoV-2 target genes using Au nanoparticles-internalized Au nanodimple substrates

Yixuan Wu et al.

Summary: The AuNDS-based SERS-PCR detection method can shorten the diagnosis time by reducing the number of cycles needed, compared to traditional RT-PCR, with lower target DNA concentration requirements.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Chemistry, Analytical

A versatile technique based on surface-enhanced Raman spectroscopy for label-free detection of amino acids and peptide formation in body fluids

Xiaoqing Wang et al.

Summary: In this work, a new surface-enhanced Raman spectroscopy method was developed for label-free and accurate fingerprint determination of nonaromatic amino acids. By using a reducing agent and an aggregator, the detection of amino acid molecules on the surface of silver nano-substrates was successfully achieved.

MICROCHIMICA ACTA (2022)

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Article Chemistry, Analytical

A photochemical approach to anchor Au NPs on MXene as a prominent SERS substrate for ultrasensitive detection of chlorpromazine

Nazar Riswana Barveen et al.

Summary: In this study, the SERS activity of titanium carbide was significantly enhanced by incorporating gold nanoparticles. The TiC/Au-NPs substrate showed a wide linear range and low limit of detection for the detection of antipsychotic drug chlorpromazine. The synergy between chemical and electromagnetic mechanisms formed hotspots between the gold nanoparticles on the TiC surface, leading to effective interaction with probe molecules. The optimized TiC/Au-NPs SERS substrate exhibited high enhancement factor and good uniformity and reproducibility.

MICROCHIMICA ACTA (2022)

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Article Chemistry, Analytical

Core-shell structured gold nanorods on thread-embroidered fabric-based microfluidic device for Ex Situ detection of glucose and lactate in sweat

Zhiqi Zhao et al.

Summary: A textile-based microfluidic device integrated with SERS technology and colorimetric assay was developed for accurate detection and evaluation of lactate, glucose, and local sweat loss in human sweat.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

Live-cell profiling of membrane sialic acids by fluorescence imaging combined with SERS labelling

Jian Lv et al.

Summary: The study presents a highly efficient and convenient two-step tagging strategy for live-cell profiling of membrane sialic acids using fluorescence imaging and SERS labeling. By using tumor markers as model proteins, sialic acids can be partitioned into distinct space domains, allowing for classification of various types of cells. This strategy provides a robust and versatile platform for highly detailed analysis of cell surface saccharide profiles, with potential applications in optical biosensing and molecular diagnosis.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Spectroscopy

Assessment of three SERS approaches for studying E. Coli O157:H7 susceptibility to ampicillin

Joshua C. Gukowsky et al.

Summary: This study successfully differentiated between ampicillin-sensitive and resistant E. coli strains using three different SERS analytical approaches, with extracellular matrix analysis and filter mapping proving to be more effective than the conventional method. There were some significant differences in the spectra obtained from the different techniques, and the potential advantages and disadvantages of each approach should be considered for future use.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Spectroscopy

A rapid and facile analytical approach to detecting Salmonella Enteritidis with aptamer-based surface-enhanced Raman spectroscopy

Lei Jin et al.

Summary: This study presents an aptamer-based surface enhanced Raman spectroscopy (SERS) method for rapid detection of Salmonella Enteritidis. The method utilizes a handheld Raman instrument and shows high specificity, quick detection time, and quantitative determination of Salmonella Enteritidis. It offers a promising alternative for on-site detection of Salmonella Enteritidis.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Spectroscopy

Diagnosis and staging of diffuse large B-cell lymphoma using label-free surface-enhanced Raman spectroscopy

Xue Chen et al.

Summary: Non-invasive diagnosis and staging of diffuse large B-cell lymphoma (DLBCL) were achieved using label free surface-enhanced Raman spectroscopy (SERS) in combination with multivariate analysis methods. The k-nearest neighbors (kNN) classifier model showed the best performance for both diagnosis and staging of DLBCL, with high accuracy, sensitivity, and specificity values. The results demonstrate the potential of label-free serum SERS combined with multivariate analysis as a technique for noninvasive diagnosis and staging of DLBCL.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Spectroscopy

SERS-based DNA methylation profiling allows the differential diagnosis of malignant lymphadenopathy

Andrei Stefancu et al.

Summary: This study demonstrates the potential of using SERS to differentiate between different lymphoma types and lymph node metastasis based on specific DNA signals. The variations in bands at 1005 cm-1 and 730 cm-1 play a key role in distinguishing malignant and non-malignant DNA. By utilizing the area ratio of these SERS bands as input, effective differentiation between various lymphomas can be achieved, with a high accuracy rate using multivariate data analysis techniques.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Chemistry, Analytical

Construction of a sensitive and selective plasmonic biosensor for prostate specific antigen by combining magnetic molecularly-imprinted polymer and surface-enhanced Raman spectroscopy

Eylem Turan et al.

Summary: A novel analytical method for selective and sensitive detection of prostate specific antigen (PSA) was developed by combining molecularly-imprinted polymers and surface-enhanced Raman spectroscopy (SERS). The method showed high sensitivity, selectivity, low cost, simplified detection procedure, fast response, and potential for clinical applications in determining tumor markers of prostate cancer.

TALANTA (2022)

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Review Medical Laboratory Technology

Therapeutic Drug Monitoring of Antibiotics in Critically Ill Patients: Current Practice and Future Perspectives With a Focus on Clinical Outcome

Birgit C. P. Koch et al.

Summary: Early initiation of antibiotics and correct dosing are essential for improving infections in critically ill patients. However, the altered pharmacokinetic parameters and less susceptible microorganisms pose challenges to ensuring optimal antibiotic exposure. Therapeutic drug monitoring (TDM) is a commonly used strategy to support individualized dosing of antibiotics. This review recommends implementing TDM for glycopeptides and aminoglycosides, and suggests performing TDM in specific patient cases for antibiotics such as beta-lactams, fluoroquinolones, and linezolid. Future possibilities for improving TDM include model-informed precision dosing and the use of rapid bioanalytical techniques or biosensors for real-time monitoring of drug concentrations.

THERAPEUTIC DRUG MONITORING (2022)

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Article Chemistry, Analytical

Silk fibroin-decorated with tunable Au/Ag nanodendrites: A plastic near-infrared SERS substrate with periodic microstructures for ultra-sensitive monitoring of lactic acid in human sweat

Hui Ma et al.

Summary: In this study, a plastic SERS substrate based on silk fibroin fibers decorated with Au/Ag nanodendrites was proposed. The substrate exhibited enhanced NIR-SERS activity due to its concave pyramid surface microstructures. The NIR-SERS activity was also influenced by the content of Au/Ag nanodendrites in the substrate. The substrate showed ultra-sensitive molecular detection limits and could be used for health monitoring.

VIBRATIONAL SPECTROSCOPY (2022)

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Article Chemistry, Analytical

Detection of Hypertension-Induced Changes in Erythrocytes by SERS Nanosensors

Evelina I. Nikelshparg et al.

Summary: Surface-enhanced Raman spectroscopy (SERS) is a promising tool for detecting molecular changes in cardiovascular diseases (CVDs). We used SERS nanosensors to evaluate changes in red blood cell properties under normal and hypertensive conditions in an animal model and identified pathological changes in the plasma membrane and submembrane region.

BIOSENSORS-BASEL (2022)

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Article Biophysics

A direct method for detecting proteins in body fluids by Surface-Enhanced Raman Spectroscopy under native conditions

Dan Li et al.

Summary: In this study, the aggregation of silver nanoparticles (AgNPs) was optimized using dichloromethane (DCM) and CaCl2, enabling sensitive and reproducible surface enhanced Raman spectroscopy (SERS) detection of unlabeled proteins while maintaining their native structure. The method showed good repeatability and a high quality in the analysis of protein samples. Furthermore, the technique allowed for protein quantification in mixtures and serum, and demonstrated promise for applications in food testing and clinical diagnosis.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Chemistry, Analytical

SERS-based lateral flow immunoassay strip for ultrasensitive and quantitative detection of acrosomal protein SP10

Bing Liu et al.

Summary: A novel point of care testing (POCT) device based on SERS-LFA was developed for ultrasensitive and quantitative detection of acrosomal protein SP10, showing great potential in the diagnosis of male infertility and fertility planning.

MICROCHEMICAL JOURNAL (2022)

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Article Chemistry, Analytical

Fluorescence and surface-enhanced Raman scattering dual-mode nanoprobe for monitoring telomerase activity in living cells

Siyu Luo et al.

Summary: A dual-mode functional nanosensor based on fluorescence and surface-enhanced Raman scattering (SERS) was proposed for monitoring telomerase activity. The sensor uses Cy5-functional gold nanoparticles (Au NPs) as the dual functional nanoprobe. Changes in the distance between the signaling molecule Cy5 and Au NPs result in changes in the SERS and fluorescence signals, allowing for telomerase activity monitoring.

MICROCHEMICAL JOURNAL (2022)

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Article Biochemistry & Molecular Biology

Combined miRNA and SERS urine liquid biopsy for the point-of-care diagnosis and molecular stratification of bladder cancer

Tudor Moisoiu et al.

Summary: By combining microRNA analysis and surface-enhanced Raman spectroscopy, a non-invasive, point-of-care diagnostic and molecular stratification tool for bladder cancer can be developed.

MOLECULAR MEDICINE (2022)

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Article Spectroscopy

Subtype discrimination of acute myeloid leukemia based on plasma SERS technique

Minlu Ye et al.

Summary: This study discusses the application of surface-enhanced Raman spectroscopy (SERS) in distinguishing between acute promyelocytic leukemia and acute monocytic leukemia. Using SERS technique with silver nanoparticles, the biochemical differences among different AML subtypes were explored. The results demonstrate the excellent performance of SERS technique in differentiating different AML subtypes and control groups.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Spectroscopy

SERS active fibers from wet-spinning of alginate with gold nanoparticles for pH sensing

Yue Zhang et al.

Summary: Functional composite fibers prepared by wet-spinning method were used for pH sensing based on surface enhanced Raman scattering (SERS). The fibers showed distinct SERS enhancement for low concentrations of dyes and pH dependent SERS spectra. The flexible composite fibers could be woven into a wearable wrist band for health monitoring.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Chemistry, Analytical

Long-term monitoring of blood biomarkers related to intrauterine growth restriction using AgNPs SERS tags-based lateral flow assay

Yanan Song et al.

Summary: This study presents a SERS-based double targets detection method in pregnancy, utilizing functionalized Ag nanoparticles (AgNPs) to accurately capture target proteins in blood samples and quantify them. Compared with conventional ELISA method, this method exhibits high selectivity and sensitivity.

TALANTA (2022)

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Article Chemistry, Physical

Based lateral flow immunosensor for ultrasensitive and selective surface-enhanced Raman spectroscopy stroke biomarkers detection

Yanan Song et al.

Summary: A method using surface-enhanced Raman scattering (SERS) active nanospheres combined with probe-immobilized lateral flow strip was developed to assess multiple biomarkers in blood samples of stroke patients. The method demonstrated sensitive and quantitative measures towards stroke-related MMP-9, S00-beta, and NSE, showing potential for reliable stroke diagnosis and prognosis evaluation in clinical applications. The accuracy of SERS imaging was confirmed by enzyme linked immunosorbent assay (ELISA), indicating the feasibility of this method for further quantitative analysis of molecules in blood samples.

APPLIED SURFACE SCIENCE (2022)

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Article Biophysics

A novel surface-enhanced Raman scattering (SERS) strategy for ultrasensitive detection of bacteria based on three-dimensional (3D) DNA walker

Enlai Yang et al.

Summary: The study developed a novel SERS strategy based on a three-dimensional DNA walker for quantitative analysis of Salmonella typhimurium. The method achieved high sensitivity detection of bacteria.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Biochemical Research Methods

Therapeutic prognosis of prostate cancer using surface-enhanced Raman scattering of patient urine and multivariate statistical analysis

Yiwei Ma et al.

Summary: The study utilizes SERS measurements of patient urine and biostatistical algorithms to evaluate the treatment response of prostate cancer patients. Utilizing GA-PLS-LDA analysis of Raman spectra, an accuracy of 86.6%, sensitivity of 86.0%, and specificity of 87.1% are achieved in differentiating recurrent and nonrecurrent cohorts.

JOURNAL OF BIOPHOTONICS (2021)

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Article Biochemical Research Methods

SERS-based sensor for direct L-selectin level determination in plasma samples as alternative method of tumor detection

Aneta Aniela Kowalska et al.

Summary: This study demonstrates a SERS-based sensor for determining the level of L-selectin in biological samples, which can be used in medical diagnosis. The combination of SERS with PCA enhances data analysis, and the loadings of PCA help identify important vibration modes for the assumed identification.

JOURNAL OF BIOPHOTONICS (2021)

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Article Chemistry, Multidisciplinary

Noninvasive and Highly Multiplexed Five-Color Tumor Imaging of Multicore Near-Infrared Resonant Surface-Enhanced Raman Nanoparticles In Vivo

Jung Ho Yu et al.

Summary: We demonstrate noninvasive and five-plex SERS imaging of nanoparticle accumulation in tumors of living mice using multispectral palettes of gold multicore-near-infrared (NIR) resonant Raman dyes-silica shell SERS (NIR-SERRS) nanoparticle oligomers. The method allows for ratiometric imaging of tumors by varying the administered ratio of nanoparticles, simulating the detection of multiple biomarkers with different expression levels in the tumor environment. This approach surpasses the multiplicity limit of previous preclinical tumor imaging methods while maintaining sufficient sensitivity for in vivo imaging, enabling noninvasive assessment of multiple biological targets within the tumor microenvironment in living subjects.

ACS NANO (2021)

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Article Biophysics

A SERS aptasensor based on AuNPs functionalized PDMS film for selective and sensitive detection of Staphylococcus aureus

Afang Zhu et al.

Summary: A sensitive biosensor based on aptamer-modified PDMS film was developed for the detection of Staphylococcus aureus using SERS technology, showing a linear relationship between the signal of mercaptobenzoic acid at 1085 cm(-1) and S. aureus concentration.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Biophysics

Nonmetallic SERS-based immunosensor byintegrating MoS2 nanoflower and nanosheet towards the direct serum detection of carbohydrate antigen 19-9

Jiamin Jiang et al.

Summary: Recently, nonmetallic substrates have attracted great interest in SERS-based immunoassay due to their uniformity, stability, and biocompatibility. A novel nonmetallic SERS-based immunoassay mediated by two-dimensional molybdenum disulfide (MoS2) has been developed for sensitive and specific monitoring of CA19-9, showing potential for clinical diagnosis.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Biophysics

Ultrasensitive detection of SARS-CoV-2 spike protein in untreated saliva using SERS-based biosensor

Meiling Zhang et al.

Summary: A promising SERS-based COVID-19 biosensor was proposed for ultrasensitive detection of SARS-CoV-2 virus in untreated saliva. The biosensor exhibited excellent specificity and sensitivity for early diagnosis of COVID-19.

BIOSENSORS & BIOELECTRONICS (2021)

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Review Oncology

Therapeutic drug monitoring in oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology consensus guidelines for imatinib therapy

William A. Clarke et al.

Summary: Therapeutic drug monitoring (TDM) is not widely accepted in oncology but plays an important role in other medical fields. Imatinib and other oral chemotherapy drugs use a flat dosing approach, with numerous studies examining the correlation between blood concentrations and clinical effects. The International Association identified the need to develop consensus guidelines based on available data.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Chemistry, Analytical

PCR-coupled Paper-based Surface-enhanced Raman Scattering (SERS) Sensor for Rapid and Sensitive Detection of Respiratory Bacterial DNA

Hyo Geun Lee et al.

Summary: A paper-based surface-enhanced Raman scattering (SERS) substrate was developed for rapid detection of respiratory bacterial DNA, coupled with polymerase chain reaction (PCR). The PCR-coupled SERS method showed enhanced detection capability after 10 amplification cycles, enabling low-cycle amplification and sensitive DNA sensing.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

M13 phage-based nanoprobe for SERS detection and inactivation of Staphylococcus aureus

Xiao-Yan Wang et al.

Summary: A surface-enhanced Raman scattering (SERS) nanoprobe based on M13 phages was developed for selective detection and inactivation of Staphylococcus aureus. This method allowed for quantification of S. aureus in aqueous medium and showed promising potential for multifunctional platform for simultaneous detection and inactivation of S. aureus, including bactericidal capabilities.

TALANTA (2021)

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Article Nanoscience & Nanotechnology

Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection

Yusi Peng et al.

Summary: Nb2C and Ta2C MXenes exhibit remarkable SERS performance with enhancement factors of 3.0x10^6 and 1.4x10^6, enabling sensitive detection and accurate identification of the SARS-CoV-2 spike protein. This research provides theoretical guidance for exploring novel SERS-active semiconductor-based materials and practical applications of SERS technology.

NANO-MICRO LETTERS (2021)

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Article Biochemical Research Methods

Combined negative dielectrophoresis with a flexible SERS platform as a novel strategy for rapid detection and identification of bacteria

Ariadna B. Nowicka et al.

Summary: Surface-enhanced Raman spectroscopy (SERS) has been successfully used in analytical chemistry, molecular biology, and medical diagnostics. By combining the negative dielectrophoretic (nDEP) phenomenon and a flexible SERS platform, this study demonstrates quick isolation, concentration, and label-free identification of bacteria. The platform provides a strong enhancement factor, stability, and reproducibility for the SERS response. Introducing radial dielectrophoretic forces allows for efficient bacterial cell separation, concentration, and deposition onto the SERS-active surface, enabling vibration-based detection with the hybrid DEP-SERS device. The DEP-SERS system shows potential for rapid, cultivation-free, direct detection of bacteria in samples like urine and apple juice, offering new opportunities for pathogen detection.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

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Article Biochemical Research Methods

An aptamer biosensor based dual signal amplification system for the detection of salmonella typhimurium

Ao Li et al.

Summary: This study combined immune hybridization chain reaction (HCR) with surface enhanced Raman scattering (SERS) to achieve high sensitivity detection of Salmonella typhimurium in food, showing good application potential for highly sensitive detection of other contaminants in food. The method successfully captured and detected S. typhimurium in spiked milk samples, demonstrating double amplification of the detection signal and significantly improved detection sensitivity.

ANALYTICAL BIOCHEMISTRY (2021)

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Article Chemistry, Physical

Large-area surface-enhanced Raman spectroscopy substrate by hybrid porous GaN with Au/Ag for breast cancer miRNA detection

Yingkuan Han et al.

Summary: The study successfully developed large area SERS substrates by combining Au/Ag with porous GaN nanostructures, achieving a high performance with good uniformity and stability for potential early-cancer diagnosis and ultrasensitive biosensors.

APPLIED SURFACE SCIENCE (2021)

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Article Oncology

Surface enhanced Raman spectroscopy of RNA samples extracted from blood of hepatitis C patients for quantification of viral loads

Saira Nasir et al.

Summary: The study aimed to develop a SERS-based method for qualitative and quantitative analysis of HCV from blood samples. Results showed that SERS could identify the biochemical changes associated with different viral loads in HCV-infected samples, and aid in differentiating between hepatitis-infected and healthy samples. Additionally, a PLSR model was established to determine viral loads in HCV-positive RNA samples with 99% accuracy.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Article Chemistry, Analytical

SERS-based lateral flow immunoassay for sensitive and simultaneous detection of anti-SARS-CoV-2 IgM and IgG antibodies by using gap-enhanced Raman nanotags

Shiliang Chen et al.

Summary: The newly developed SERS-based LFIA strip using GERTs achieved highly sensitive detection of anti-SARS-CoV-2 IgM and IgG, with detection limits 100 times lower compared to conventional LFIA strips, improving the accuracy and reliability of early diagnosis.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Development of a SERS-based lateral flow immunoassay for rapid and ultra-sensitive detection of anti-SARS-CoV-2 IgM/IgG in clinical samples

Haifeng Liu et al.

Summary: This study reported a surface-enhanced Raman scattering-based lateral flow immunoassay method for the high sensitivity simultaneous detection of anti-SARS-CoV-2 IgM/IgG. The method utilized custom SERS tags and dual layers of Raman dye, with signal intensities easily recorded by a portable Raman instrument for high sensitivity analysis. Validation on samples from COVID-19 patients and healthy individuals showed high accuracy and specificity.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Spectroscopy

Fuzzy characterization and classification of bacteria species detected at single-cell level by surface-enhanced Raman scattering

Nicoleta Elena Dina et al.

Summary: Advanced chemometric methods, such as fuzzy c-means and FLDA, were successfully applied for characterization and classification of bacterial species at single-cell level by SERS spectroscopy. The results demonstrated the efficiency and information power of these methods for bacterial characterization and classification based on SERS spectra.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Article Biochemical Research Methods

Detection of carbamazepine in saliva based on surface-enhanced Raman spectroscopy

Ning Chen et al.

Summary: A new method using SERS for non-invasive detection of CBZ was proposed in this study, demonstrating high sensitivity and stability. This method has the potential to replace traditional blood draw and can be applied in various biomedical sciences.

BIOMEDICAL OPTICS EXPRESS (2021)

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Article Chemistry, Multidisciplinary

In Situ Exosomal MicroRNA Determination by Target-Triggered SERS and Fe3O4@TiO2-Based Exosome Accumulation

Shuqin Jiang et al.

Summary: Exosomal microRNAs have been shown to be significant biomarkers for early cancer diagnosis. A new in situ platform for direct exosomal miRNA detection from serum samples was reported, offering a simple and sensitive method without the need for capture antibodies or ultracentrifugation. This platform enables accurate quantification of target miRNAs in situ, with potential clinical applications as a noninvasive liquid biopsy for cancer diagnostics.

ACS SENSORS (2021)

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Review Chemistry, Analytical

A Review on SERS-Based Detection of Human Virus Infections: Influenza and Coronavirus

Fernanda Savinon-Flores et al.

Summary: The diagnosis of zoonotic respiratory viruses in humans is essential due to their high pandemic threat, and surface-enhanced Raman spectroscopy (SERS) shows promising impact for virus diagnosis at point-of-care. Various strategies have been reviewed for detecting RVsZO using SERS, with both direct identification and indirect sandwich immunoassays achieving quantitative mono- and multiplexed assays. Developing multiplex assays incorporating specific biomarkers and secondary disease biomarkers for RVsZO detection would be desirable for confirming infections and evaluating patient health.

BIOSENSORS-BASEL (2021)

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Article Chemistry, Analytical

Rapid and sensitive triple-mode detection of causative SARS-CoV-2 virus speci fi c genes through interaction between genes and nanoparticles

Yakun Gao et al.

Summary: This article introduces a triple-mode biosensor based on AuNPs, which can rapidly and selectively detect viral RNA, achieving femtomole level detection limits in absorbance, fluorescence, and SERS modes. The sensor effectively minimizes false negative/positive readings of SARS-CoV-2.

ANALYTICA CHIMICA ACTA (2021)

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Article Biochemical Research Methods

Rapid identification of pathogens by using surface-enhanced Raman spectroscopy and multi-scale convolutional neural network

Jingyu Ding et al.

Summary: Salmonella is a prevalent pathogen worldwide, causing serious morbidity and mortality. The most common foodborne pathogenic serovars in the EU and China are reported to be Salmonella Enteritidis, Salmonella Typhimurium, and Salmonella Paratyphi. A new analytical method combining surface-enhanced Raman spectroscopy with multi-scale convolutional neural network was developed to efficiently detect and distinguish these serovars, achieving a recognition accuracy of over 97%. The findings suggest the feasibility of combining SERS spectroscopy with multi-scale CNN not only for Salmonella serotype identification, but also for other pathogen species and serovar identifications.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

Detection of Estrogen Receptor Alpha and Assessment of Fulvestrant Activity in MCF-7 Tumor Spheroids Using Microfluidics and SERS

Anastasia Kapara et al.

Summary: Breast cancer is a leading cause of cancer death in women. Functionalized nanoparticles were utilized to detect ERα expression, providing insights into the efficiency of targeted nanotags.

ANALYTICAL CHEMISTRY (2021)

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Review Chemistry, Analytical

Multiplexed Liquid Biopsy and Tumor Imaging Using Surface-Enhanced Raman Scattering

Francesco Dell'Olio

Summary: Recent advancements in liquid biopsy and oncological imaging have greatly improved cancer care through the application of SERS technology, which enhances detection sensitivity and clinical utility in the field.

BIOSENSORS-BASEL (2021)

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Article Chemistry, Analytical

Aptamer-functionalized Au nanoparticles array as the effective SERS biosensor for label-free detection of interleukin-6 in serum

Muhammad Muhammad et al.

Summary: This study successfully developed a label-free biosensor for detecting interleukin-6 and achieved quantitative evaluation in a low concentration range. The research indicates that the aptamer-based SERS biosensor can be a promising tool for quick and convenient medical diagnosis applications.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Engineering, Environmental

Ultra-fast and onsite interrogation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in waters via surface enhanced Raman scattering (SERS)

Dayi Zhang et al.

Summary: This study developed a method using surface enhanced Raman scattering (SERS) to detect SARS-CoV-2 rapidly without any pretreatment. The accuracy and easy-operation of on-site tests on water samples proved its feasibility for evaluating disinfection performance, exploring viral survival, and tracking viral transmission in pipe networks.

WATER RESEARCH (2021)

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Article Nanoscience & Nanotechnology

Human ACE2-Functionalized Gold Virus-Trap Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection

Yong Yang et al.

Summary: The study presents a highly sensitive SERS biosensor based on a Human ACE2-functionalized gold virus traps nanostructure for selective capture and rapid detection of S-protein expressed coronavirus, such as the current SARS-CoV-2, down to the single-virus level.

NANO-MICRO LETTERS (2021)

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Review Chemistry, Multidisciplinary

Applications of Surface-Enhanced Raman Scattering in Biochemical and Medical Analysis

Aleksandra Szaniawska et al.

Summary: The mini-review briefly describes the applications of surface-enhanced Raman spectroscopy (SERS) in determining important biochemically species, focusing on its medical significance and potential as an alternative to traditional diagnostic methods in clinics. The review also explains how SERS-based sensors operate and highlights future prospects in this field.

FRONTIERS IN CHEMISTRY (2021)

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Article Hematology

Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia

Rikke Hebo Larsen et al.

Summary: The addition of 6-thioguanine to maintenance therapy significantly increases DNA-TG levels, potentially reducing the risk of ALL relapse.

HAEMATOLOGICA (2021)

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Article Chemistry, Multidisciplinary

SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

Elena Zavyalova et al.

Summary: This paper presents a SERS-aptasensor based on colloidal solutions for rapid and specific quantitative determination of the SARS-CoV-2 virus, distinguishing it from other respiratory viruses. Existing SERS-based aptasensors for virus detection often lack quantification or are complex and costly in their design and implementation.

NANOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Sensitive Detection of SARS-CoV-2 Using a SERS-Based Aptasensor

Hao Chen et al.

Summary: The newly developed SERS-based aptasensor platform showed high sensitivity in quantifying SARS-CoV-2 lysates, enabling sensitive detection through monitoring changes in SERS peak intensity.

ACS SENSORS (2021)

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Article Chemistry, Multidisciplinary

Detection of SARS-CoV-2 and its S and N proteins using surface enhanced Raman spectroscopy

John Eder Sanchez et al.

Summary: The COVID-19 pandemic highlighted the importance of accurate and rapid virus testing. The use of Surface Enhanced Raman Spectroscopy (SERS) with novel nanomaterials can provide distinct spectroscopic signatures of the SARS-CoV-2 virus, offering a fast, inexpensive, and reliable clinical testing method. Additionally, SERS can be utilized for analyzing structural changes in virus proteins, showcasing the application of nanotechnology in health and social issues.

RSC ADVANCES (2021)

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Review Nanoscience & Nanotechnology

SERS Based Lateral Flow Immunoassay for Point-of-Care Detection of SARS-CoV-2 in Clinical Samples

Shalu Yadav et al.

Summary: The ongoing COVID-19 pandemic has created a significant burden on the global healthcare system, necessitating a rapid, user-friendly, and cost-effective on-site monitoring system for diagnosis. This review discusses the integration of SERS with LFIA for quantitative analysis of SARS-CoV-2 as a solution to the limitations of existing methods.

ACS APPLIED BIO MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Beehive-Inspired Macroporous SERS Probe for Cancer Detection through Capturing and Analyzing Exosomes in Plasma

Shilian Dong et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Label-Free Surface-Enhanced Raman Spectroscopy Biosensor for On-Site Breast Cancer Detection Using Human Tears

Soogeun Kim et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Analytical

Liquid-liquid extraction-assisted SERS-based determination of sulfamethoxazole in spiked human urine

Natalia E. Markina et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Analytical

Tetrahedron Probes for Ultrasensitive In Situ Detection of Telomerase and Surface Glycoprotein Activity in Living Cells

Xiao Guo et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Target MicroRNA-Responsive DNA Hydrogel-Based Surface-Enhanced Raman Scattering Sensor Arrays for MicroRNA-Marked Cancer Screening

Yanmei Si et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

SERS Platform for Dengue Diagnosis from Clinical Samples Employing a Hand Held Raman Spectrometer

S. K. Gahlaut et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Surface Enhanced Raman Spectroscopy for Quantitative Analysis: Results of a Large-Scale European Multi-Instrument Interlaboratory Study

Stefano Fornasaro et al.

ANALYTICAL CHEMISTRY (2020)

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Article Biophysics

Using SERS-based microfluidic paper-based device (μPAD) for calibration-free quantitative measurement of AMI cardiac biomarkers

Wei Yin Lim et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Chemistry, Physical

Direct Detection of Bacteria Using Positively Charged Ag/Au Bimetallic Nanoparticles: A Label-free Surface-Enhanced Raman Scattering Study Coupled with Multivariate Analysis

Om Prakash et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2020)

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Article Chemistry, Physical

SERS Nanoprobe for Intracellular Monitoring of Viral Mutations

Kholud Dardir et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2020)

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Article Multidisciplinary Sciences

Quantum scale organic semiconductors for SERS detection of DNA methylation and gene expression

Swarna Ganesh et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Early-Stage Lung Cancer Diagnosis by Deep Learning-Based Spectroscopic Analysis of Circulating Exosomes

Hyunku Shin et al.

ACS NANO (2020)

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Article Biophysics

SERS biosensors for ultrasensitive detection of multiple biomarkers expressed in cancer cells

Namhyun Choi et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Chemistry, Analytical

A highly sensitive SERS quenching nanosensor for the determination of tumor necrosis factor alpha in blood

Mahnaz D. Gholami et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Multidisciplinary

Design of Magnetic-Plasmonic Nanoparticle Assemblies via Interface Engineering of Plasmonic Shells for Targeted Cancer Cell Imaging and Separation

Myeong Soo Kim et al.

SMALL (2020)

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Article Chemistry, Analytical

Rapid and sensitive identification of uropathogenic Escherichia coli using a surface-enhanced-Raman-scattering-based biochip

Cristina-Cassiana Andrei et al.

TALANTA (2020)

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Article Optics

Surface-enhanced Raman spectroscopy for antiplatelet therapy effectiveness assessment

Andrey Zyubin et al.

LASER PHYSICS LETTERS (2020)

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Article Biochemical Research Methods

Determination of methotrexate in spiked human urine using SERS-active sorbent

Natalia E. Markina et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Biochemical Research Methods

SERS-based lateral flow assay combined with machine learning for highly sensitive quantitative analysis of Escherichia coli O157:H7

Shuaishuai Yan et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Stealth modified bottom up SERS substrates for label-free therapeutic drug monitoring of doxorubicin in blood serum

Sandeep Surendra Panikar et al.

TALANTA (2020)

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Article Nanoscience & Nanotechnology

Sensitive and Label-Free SERS Detection of Single-Stranded DNA Assisted by Silver Nanoparticles and Gold-Coated Magnetic Nanoparticles

Zhao Yu et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Biochemical Research Methods

Rapid and label-free urine test based on surface-enhanced Raman spectroscopy for the non-invasive detection of colorectal cancer at different stages

Jinyong Lin et al.

BIOMEDICAL OPTICS EXPRESS (2020)

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Article Chemistry, Analytical

Copper nanoparticles for SERS-based determination of some cephalosporin antibiotics in spiked human urine

Natalia E. Markina et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Medicine, Research & Experimental

Polymerase chain reaction - surface-enhanced Raman spectroscopy (PCR-SERS) method for gene methylation level detection in plasma

Xiaozhou Li et al.

THERANOSTICS (2020)

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Review Materials Science, Biomaterials

Recent progress of SERS optical nanosensors for miRNA analysis

Yudie Sun et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Nanoscience & Nanotechnology

Ultrasensitive Detection of Circulating Tumor DNA of Lung Cancer via an Enzymatically Amplified SERS-Based Frequency Shift Assay

Jie Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Pharmacology & Pharmacy

The rationale of dose-response curves in selecting cancer drug dosing

Jennifer H. Martin et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)

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Article Chemistry, Analytical

Aptamer-based SERS biosensor for whole cell analytical detection of E. coli O157:H7

Susana Diaz-Amaya et al.

ANALYTICA CHIMICA ACTA (2019)

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Article Chemistry, Analytical

Optofluidic label-free SERS platform for rapid bacteria detection in serum

Robert Hunter et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Article Nanoscience & Nanotechnology

The role of Ag+, Ca2+, Pb2+ and Al3+ adions in the SERS turn-on effect of anionic analytes

Stefania D. Iancu et al.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Surface Enhanced Raman Spectroscopy for DNA Biosensors-How Far Are We?

Edyta Pyrak et al.

MOLECULES (2019)

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Review Chemistry, Multidisciplinary

Direct surface-enhanced Raman scattering (SERS) spectroscopy of nucleic acids: from fundamental studies to real-life applications

Eduardo Garcia-Rico et al.

CHEMICAL SOCIETY REVIEWS (2018)

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Article Allergy

MicroRNA

Thomas X. Lu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Spectroscopy

Label-free SERS in biological and biomedical applications: Recent progress, current challenges and opportunities

Xiao-Shan Zheng et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2018)

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Article Chemistry, Multidisciplinary

Reporter Selection for Nanotags in Multiplexed Surface Enhanced Raman Spectroscopy Assays

Maria Sanchez-Purra et al.

ACS OMEGA (2018)

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Review Biochemistry & Molecular Biology

DNA methylation: an epigenetic mark of cellular memory

Mirang Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

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Review Chemistry, Multidisciplinary

Multiplex in vitro detection using SERS

Stacey Laing et al.

CHEMICAL SOCIETY REVIEWS (2016)

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Review Chemistry, Analytical

Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review

Aleksandra Jaworska et al.

BIOSENSORS-BASEL (2016)

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Article Chemistry, Multidisciplinary

Guiding Brain Tumor Resection Using Surface-Enhanced Raman Scattering Nanoparticles and a Hand-Held Raman Scanner

Hazem Karabeber et al.

ACS NANO (2014)

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Article Chemistry, Physical

Hollow and Solid Metallic Nanoparticles in Sensing and in Nanocatalysis

Mahmoud A. Mahmoud et al.

CHEMISTRY OF MATERIALS (2014)

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Review Oncology

KRAS Mutation: Should We Test for It, and Does It Matter?

Patrick J. Roberts et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

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Article Multidisciplinary Sciences

The Prognostic Value of BRAF Mutation in Colorectal Cancer and Melanoma: A Systematic Review and Meta-Analysis

Gholamreza Safaee Ardekani et al.

PLOS ONE (2012)

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Editorial Material Biotechnology & Applied Microbiology

Doxorubicin pathways: pharmacodynamics and adverse effects

Caroline F. Thorn et al.

PHARMACOGENETICS AND GENOMICS (2011)

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Review Oncology

Cell-free nucleic acids as biomarkers in cancer patients

Heidi Schwarzenbach et al.

NATURE REVIEWS CANCER (2011)

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Article Education, Scientific Disciplines

Surface-Enhanced Raman Spectroscopy Recent Advancement of Raman Spectroscopy

Ujjal Kumar Sur

RESONANCE-JOURNAL OF SCIENCE EDUCATION (2010)

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Article Multidisciplinary Sciences

Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy

Cristina L. Zavaleta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Chemistry, Physical

Raman spectroscopy of surfaces

Andrzej Kudelski

SURFACE SCIENCE (2009)

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Review Oncology

BRAF mutation in thyroid cancer

M Xing

ENDOCRINE-RELATED CANCER (2005)

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Article Chemistry, Physical

Electromagnetic fields around silver nanoparticles and dimers

E Hao et al.

JOURNAL OF CHEMICAL PHYSICS (2004)

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Article Chemistry, Physical

The optical properties of metal nanoparticles: The influence of size, shape, and dielectric environment

KL Kelly et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2003)

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