4.7 Review

Microfluidic Organ-on-a-Chip System for Disease Modeling and Drug Development

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Engineering, Biomedical

Enabling peristalsis of human colon tumor organoids on microfluidic chips

Guocheng Fang et al.

Summary: This study presents a method to model peristalsis in human colon tumor organoids on a microfluidic chip. The chip allows the control of peristalsis amplitude and rhythm, and enables high throughput culture of organoids. Results show the importance of mimicking mechanical stimuli in the physiological environment when evaluating nanoparticles in vitro.

BIOFABRICATION (2022)

Article Chemistry, Multidisciplinary

Electroconductive and Anisotropic Structural Color Hydrogels for Visual Heart-on-a-Chip Construction

Lingyu Sun et al.

Summary: In this paper, the authors present a novel electroconductive and anisotropic structural color hydrogel for constructing a visualized heart-on-a-chip system. The hydrogel can induce the alignment of cardiomyocytes and contribute to their synchronous beating, allowing for dynamic cardiomyocyte sensing and drug screening.

ADVANCED SCIENCE (2022)

Article Biotechnology & Applied Microbiology

A Bioprinted Heart-on-a-Chip with Human Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Evaluation

Alan Faulkner-Jones et al.

Summary: In this study, it was found that valve-based bioprinting had no measurable detrimental effects on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The use of bio-ink droplets containing a liquid suspension of live cardiomyocytes was proven to be an alternative to standard manual handling and could reduce the number of cells required for drug testing, with no significant differences in drug-sensitivity between both approaches.

BIOENGINEERING-BASEL (2022)

Article Cell & Tissue Engineering

Bone Microvasculature: Stimulus for Tissue Function and Regeneration

Eun-Jin Lee et al.

Summary: Bone is highly vascularized and alterations in vasculature can lead to bone diseases. Understanding the role of vasculature in bone diseases and utilizing tissue engineering strategies, particularly involving stem cells and growth factors, will contribute to bone therapeutics.

TISSUE ENGINEERING PART B-REVIEWS (2021)

Article Chemistry, Multidisciplinary

3D Microfluidic Platform and Tumor Vascular Mapping for Evaluating Anti-Angiogenic RNAi-Based Nanomedicine

Somin Lee et al.

Summary: The development of a strategy based on 3D microfluidic angiogenesis-on-a-chip and 3D tumor vascular mapping allows for efficient evaluation of RNAi-based antiangiogenic nanomedicine. The strategy enables replication of functional 3D angiogenesis in vitro, extraction of complex morphological information of tumor vasculature, and observation of sub-regional differences in antiangiogenic effects.

ACS NANO (2021)

Article Biotechnology & Applied Microbiology

In vitro hepatic steatosis model based on gut-liver-on-a-chip

Joong-Won Jeon et al.

Summary: The development of a microfluidic gut-liver chip capable of recapitulating gut absorption of fatty acids and subsequent lipid accumulation in liver cells was reported. A series of experiments were conducted to verify the chip's ability to reproduce various aspects of hepatic steatosis, including evaluating fatty acid absorption and testing the anti-steatotic effects of drugs with different mechanisms of action. The study demonstrated the gut-liver chip's potential as a novel and physiologically realistic in vitro model for studying fatty liver disease.

BIOTECHNOLOGY PROGRESS (2021)

Article Instruments & Instrumentation

Photolithography-free Vessel-on-a-chip to Simulate Tumor Cell Extravasation

Yuichiro Asaumi et al.

Summary: A photolithography-free vessel-on-a-chip (VOC) was developed to simulate tumor cell extravasation, showing directional migration of tumor cells in the presence of chemical gradients and inhibition by specific inhibitors. The device allows for studying the mechanism of transendothelial migration of tumor cells and screening anti-metastatic drug candidates.

SENSORS AND MATERIALS (2021)

Article Engineering, Biomedical

Fabrication of PDMS microfluidic devices using nanoclay-reinforced Pluronic F-127 as a sacrificial ink

Kui Zhou et al.

Summary: The research utilized 3D printing of nanoclay-reinforced Pluronic ink as a sacrificial material to fabricate templates for microfluidic devices, demonstrating the effect of shear stress on cell morphology within channels through the construction of a human blood vessel-on-a-chip model.

BIOMEDICAL MATERIALS (2021)

Article Biochemical Research Methods

Lymphangion-chip: a microphysiological system which supports co-culture and bidirectional signaling of lymphatic endothelial and muscle cells

Amirali Selahi et al.

Summary: A new fabrication technique was developed to create a lymphangion-chip, consisting of both endothelial cells and muscle cells. This organ-on-chip successfully mimics the organization and function of lymphatic vessels in vivo. The platform provides insights into lymphatic and blood mechanobiology, inflammation, and translational outcomes.

LAB ON A CHIP (2021)

Article Chemistry, Physical

Blood vessel-on-a-chip examines the biomechanics of microvasculature

Paul F. Salipante et al.

Summary: The study utilizes a three-dimensional microvascular platform to measure the elasticity and membrane permeability of endothelial cell layer. By applying pressure through a pneumatic pressure controller, deformation is measured to obtain Young's modulus of the cell layer. This approach is capable of probing the mechanical properties of blood vessels in vitro and serves as a methodology for investigating microvascular related diseases.

SOFT MATTER (2021)

Article Instruments & Instrumentation

Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems

Egor Egorov et al.

Summary: The field of nanotechnology and personalised medicine is undergoing drastic changes in experimentation methods and efficiency, with a focus on combining automation with artificial intelligence to optimize targeted therapeutic nanoparticles.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

Article Biology

Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane

Pauline Zamprogno et al.

Summary: A new generation lung-on-a-chip utilizing a biological membrane made of collagen and elastin has been developed to mimic an array of tiny alveoli with in vivo-like dimensions. This membrane outperforms traditional PDMS in terms of stability, biodegradability, and tunability, offering the potential to more accurately reproduce air-blood barrier functions.

COMMUNICATIONS BIOLOGY (2021)

Article Chemistry, Multidisciplinary

A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health-Related Biomarkers

Rongyan He et al.

Summary: The colorimetric dermal tattoo biosensor developed in this study allows for simultaneous detection and monitoring of multiple health-related biomarkers, showing great potential for long-term health monitoring with its features of minimal invasion, easy operation, and equipment-free result reading.

ADVANCED SCIENCE (2021)

Article Biochemical Research Methods

Microfluidic integration of regeneratable electrochemical affinity-based biosensors for continual monitoring of organ-on-a-chip devices

Julio Aleman et al.

Summary: This article details the integration of sensors on organ-on-chips for continuous monitoring of biomarkers, along with the fabrication and utilization of related technologies.

NATURE PROTOCOLS (2021)

Review Engineering, Biomedical

Organ-on-a-chip platforms for accelerating the evaluation of nanomedicine

Xi Chen et al.

Summary: Nanomedicine involves the use of nanoscale materials in diagnostic and therapeutic applications, with challenges in clinical translation due to difficulty in understanding nanomaterial behaviors in human environments. Organ Chip technology offers a promising solution by enabling in vitro simulation of in vivo microenvironments for robust evaluation of nanomedicine.

BIOACTIVE MATERIALS (2021)

Article Multidisciplinary Sciences

High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro

A. L. Gard et al.

Summary: This study integrates human primary airway epithelial cells into a custom-engineered 96-device platform, and applies it to evaluate viral infection kinetics and antiviral agent dosing for influenza A virus and coronavirus infections across various human primary cell populations. This new capability can help address the rapid assessment of therapeutic efficacy against respiratory viruses, including coronaviruses.

SCIENTIFIC REPORTS (2021)

Article Chemistry, Multidisciplinary

Microvessel-on-Chip Fabrication for the In Vitro Modeling of Nanomedicine Transport

Sergio Davila et al.

Summary: Tumor-on-chip devices are being developed as an ideal platform for in vitro testing and development of onco-nanomedicine, allowing for the recreation of a physiological microenvironment. This study introduces a strategy to produce an artificial microvessel on-a-chip device with round geometries for studying nanomedicine transport dynamics in a physiologically relevant manner. The microchannels mimic tumor capillaries and are created through a thermal nanoimprint step with square-shaped channel structures produced by traditional silicon micromachining or stereolithography 3D printing.

ACS OMEGA (2021)

Review Engineering, Biomedical

Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

Rick Xing Ze Lu et al.

Summary: Nanoparticles have raised concerns due to potential adverse health effects, necessitating the development of physiologically relevant models for toxicity assessment. Organ-on-a-chip models offer a new avenue for nanotoxicological research by recapitulating in vivo microenvironment and responses.

BIOACTIVE MATERIALS (2021)

Article Biotechnology & Applied Microbiology

Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors

Marina Llenas et al.

Summary: Tumor vessel-on-a-chip systems can accurately recapitulate the features of tumor-derived vascular networks, but face challenges in treating rare conditions such as massive thrombi and bleeding. Replicating these pathophysiological events can provide insights into vascular tumors and may have applications in vascular-related diseases.

BIOENGINEERING-BASEL (2021)

Article Biochemical Research Methods

Construction of a high fidelity epidermis-on-a-chip for scalable in vitro irritation evaluation

Jing Zhang et al.

Summary: 3D skin equivalents have limitations in in vitro safety evaluation models due to troublesome operation procedures and low throughput. Organ-on-a-chip offers a solution by providing an automated and modular way for constructing and detecting skin models. In this research, an integrated epidermis-on-a-chip system was successfully developed, showing histological features similar to normal human epidermis and high barrier function. The system can detect known toxins and non-toxins and predict different irritation responses, providing a potential alternative for in vitro skin irritation evaluation.

LAB ON A CHIP (2021)

Article Biochemical Research Methods

Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers

Rachael K. Jayne et al.

Summary: This study presents a microfluidic platform for engineering cardiac microtissues, which applies external pressure waves to generate controllable time-dependent forces and transduces oscillatory forces produced by microtissues into measurable electrical outputs. The authors demonstrate the potential of this platform by studying the response of cardiac microtissues to mechanical loading and pacing.

LAB ON A CHIP (2021)

Article Gastroenterology & Hepatology

Human Nonalcoholic Steatohepatitis on a Chip

May S. Freag et al.

Summary: NASH, an advanced stage of NAFLD, is a growing global health problem without specific treatments. Researchers have successfully developed a NASH-on-a-chip platform that can mimic NASH progression and test novel anti-NASH drugs.

HEPATOLOGY COMMUNICATIONS (2021)

Review Gastroenterology & Hepatology

Liver-on-a-Chip Models of Fatty Liver Disease

Shabir Hassan et al.

HEPATOLOGY (2020)

Article Chemistry, Multidisciplinary

Side-effect test of sorafenib using 3-D skin equivalent based on microfluidic skin-on-a-chip

Hye Mi Jeon et al.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2020)

Article Engineering, Biomedical

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

Richard Novak et al.

NATURE BIOMEDICAL ENGINEERING (2020)

Article Materials Science, Biomaterials

Assessment of Air Pollutant PM2.5 Pulmonary Exposure Using a 3D Lung-on-Chip Model

Cong Xu et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Article Biotechnology & Applied Microbiology

Establishment and Application of Peristaltic Human Gut-Vessel Microsystem for Studying Host-Microbial Interaction

Bolin Jing et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

Testing the Effectiveness of Curcuma longa Leaf Extract on a Skin Equivalent Using a Pumpless Skin-on-a-Chip Model

Kyunghee Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Engineering, Biomedical

Microfluidic organ-on-a-chip models of human liver tissue

Ehsanollah Moradi et al.

ACTA BIOMATERIALIA (2020)

Article Engineering, Electrical & Electronic

Real-time physiological sensor-based liver-on-chip device for monitoring drug toxicity

Hafiz Muhammad Umer Farooqi et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2020)

Article Pharmacology & Pharmacy

Investigation of absorption, metabolism and toxicity of ginsenosides compound K based on human organ chips

Dongdong Liu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Article Engineering, Biomedical

High-Throughput Tumor-on-a-Chip Platform to Study Tumor-Stroma Interactions and Drug Pharmacokinetics

Chun-Wei Chi et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Article Engineering, Biomedical

Drug compound screening in single and integrated multi-organoid body-on-a-chip systems

Aleksander Skardal et al.

BIOFABRICATION (2020)

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2019 Update A Report From the American Heart Association

Emelia J. Benjamin et al.

CIRCULATION (2019)

Article Microbiology

The neuroactive potential of the human gut microbiota in quality of life and depression

Mireia Valles-Colomer et al.

NATURE MICROBIOLOGY (2019)

Review Multidisciplinary Sciences

Organoids-on-a-chip

Sunghee Estelle Park et al.

SCIENCE (2019)

Article Chemistry, Analytical

Chip modularity enables molecular information access from organ-on-chip devices with quality control

Wu Shang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

Article Cell Biology

Reproducing human and cross-species drug toxicities using a Liver-Chip

Kyung-Jin Jang et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Engineering, Biomedical

Bioprinting a 3D vascular construct for engineering a vessel-on-a-chip

Mieradilijiang Abudupataer et al.

BIOMEDICAL MICRODEVICES (2019)

Review Chemistry, Multidisciplinary

Advances in dynamic microphysiological organ-on-a-chip: Design principle and its biomedical application

Sang Hun Lee et al.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2019)

Review Pharmacology & Pharmacy

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

Rachelle Prantil-Baun et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)

Article Biotechnology & Applied Microbiology

Gut-liver on a chip toward an in vitro model of hepatic steatosis

Seung Yeon Lee et al.

BIOTECHNOLOGY AND BIOENGINEERING (2018)

Article Engineering, Biomedical

A Three-Dimensional Arrayed Microfluidic Blood-Brain Barrier Model With Integrated Electrical Sensor Array

Sehoon Jeong et al.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2018)

Review Biochemical Research Methods

Powering ex vivo tissue models in microfluidic systems

Ian C. McLean et al.

LAB ON A CHIP (2018)

Review Biochemistry & Molecular Biology

Extracellular matrix in lung development, homeostasis and disease

Yong Zhou et al.

MATRIX BIOLOGY (2018)

Article Multidisciplinary Sciences

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Collin D. Edington et al.

SCIENTIFIC REPORTS (2018)

Article Toxicology

A 3D human lung-on-a-chip model for nanotoxicity testing

Min Zhang et al.

TOXICOLOGY RESEARCH (2018)

Article Biochemical Research Methods

A lung/liver-on-a-chip platform for acute and chronic toxicity studies

David Bovard et al.

LAB ON A CHIP (2018)

Article Biotechnology & Applied Microbiology

Microfluidic Blood-Brain Barrier Model Provides In Vivo-Like Barrier Properties for Drug Permeability Screening

Ying I. Wang et al.

BIOTECHNOLOGY AND BIOENGINEERING (2017)

Article Multidisciplinary Sciences

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

Yu Shrike Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Chemistry, Analytical

Point-of-care-testing of nucleic acids by microfluidics

Lu Zhang et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2017)

Article Multidisciplinary Sciences

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

Shuo Xiao et al.

NATURE COMMUNICATIONS (2017)

Article Biotechnology & Applied Microbiology

Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk

Wen L. K. Chen et al.

BIOTECHNOLOGY AND BIOENGINEERING (2017)

Article Pharmacology & Pharmacy

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

Nikolaos Tsamandouras et al.

AAPS JOURNAL (2017)

Article Engineering, Biomedical

Microfluidic gut-on-a-chip with three-dimensional villi structure

Kyu-Young Shim et al.

BIOMEDICAL MICRODEVICES (2017)

Article Biochemistry & Molecular Biology

Small molecule absorption by PDMS in the context of drug response bioassays

B. J. van Meer et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Chemistry, Multidisciplinary

Microfl uidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink

Cristina Colosi et al.

ADVANCED MATERIALS (2016)

Article Medicine, General & Internal

US Emergency Department Visits for Outpatient Adverse Drug Events, 2013-2014

Nadine Shehab et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Review Biochemistry & Molecular Biology

Cardiac Meets Skeletal: What's New in Microfluidic Models for Muscle Tissue Engineering

Roberta Visone et al.

MOLECULES (2016)

Article Cell Biology

A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat

Ahyeon Koh et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Chemistry, Multidisciplinary

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

Fuyin Zheng et al.

Review Biotechnology & Applied Microbiology

Kidney-on-a-Chip Technology for Drug-Incuced Nephrotoxiciy Screening

Martijn J. Wilmer et al.

TRENDS IN BIOTECHNOLOGY (2016)

Article Multidisciplinary Sciences

A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process

Fan An et al.

SCIENTIFIC REPORTS (2016)

Article Biochemical Research Methods

Collagen-based brain microvasculature model in vitro using three-dimensional printed template

Jeong Ah Kim et al.

BIOMICROFLUIDICS (2015)

Article Pharmacology & Pharmacy

Chip-based human liver-intestine and liver-skin co-cultures - A first step toward systemic repeated dose substance testing in vitro

Ilka Maschmeyer et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Article Biology

The human gut resistome

Willem van Schaik

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

Article Multidisciplinary Sciences

Self-organizing human cardiac microchambers mediated by geometric confinement

Zhen Ma et al.

NATURE COMMUNICATIONS (2015)

Review Chemistry, Analytical

Microfluidic approaches for epithelial cell layer culture and characterisation

Roland Thuenauer et al.

ANALYST (2014)

Article Biochemical Research Methods

Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro

Yu-suke Torisawa et al.

NATURE METHODS (2014)

Article Biochemical Research Methods

Microfluidic heart on a chip for higher throughput pharmacological studies

Ashutosh Agarwal et al.

LAB ON A CHIP (2013)

Article Biochemical Research Methods

Microfabrication of human organs-on-chips

Dongeun Huh et al.

NATURE PROTOCOLS (2013)

Review Neurosciences

Impedance-based cell monitoring: barrier properties and beyond

Kathrin Benson et al.

FLUIDS AND BARRIERS OF THE CNS (2013)

Review Endocrinology & Metabolism

Drug transport across the blood-brain barrier

William M. Pardridge

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Editorial Material Multidisciplinary Sciences

TISSUE ENGINEERING Blood vessels on a chip

Claudio Franco et al.

NATURE (2012)

Review Cardiac & Cardiovascular Systems

Gut-liver axis: The impact of gut microbiota on non alcoholic fatty liver disease

D. Compare et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2012)

Article Physiology

Pathophysiology of Acute Kidney Injury

David P. Basile et al.

COMPREHENSIVE PHYSIOLOGY (2012)

Review Engineering, Biomedical

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

M. B. Esch et al.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 13 (2011)

Review Pharmacology & Pharmacy

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

Malcolm Rowland et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011 (2011)

Article Biochemical Research Methods

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

Yosuke Nakao et al.

BIOMICROFLUIDICS (2011)

Article Biochemical Research Methods

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model

Jong Hwan Sung et al.

LAB ON A CHIP (2011)

Article Biochemical Research Methods

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

Anna Grosberg et al.

LAB ON A CHIP (2011)

Review Neurosciences

Looking at the blood-brain barrier: Molecular anatomy and possible investigation approaches

Filipa Lourenco Cardoso et al.

BRAIN RESEARCH REVIEWS (2010)

Review Chemistry, Multidisciplinary

Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications

Daniel Mark et al.

CHEMICAL SOCIETY REVIEWS (2010)

Article Multidisciplinary Sciences

Reconstituting Organ-Level Lung Functions on a Chip

Dongeun Huh et al.

SCIENCE (2010)

Review Oncology

Why are tumour blood vessels abnormal and why is it important to know?

J. A. Nagy et al.

BRITISH JOURNAL OF CANCER (2009)

Article Biochemical Research Methods

A microfluidic 3D hepatocyte chip for drug toxicity testing

Yi-Chin Toh et al.

LAB ON A CHIP (2009)

Article Ethics

Are animal models predictive for humans?

Niall Shanks et al.

Philosophy Ethics and Humanities in Medicine (2009)

Article Biotechnology & Applied Microbiology

The emerging nanomedicine landscape

Volker Wagner et al.

NATURE BIOTECHNOLOGY (2006)

Review Neurosciences

Astrocyte-endothelial interactions at the blood-brain barrier

NJ Abbott et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Review Pharmacology & Pharmacy

The blood-brain barrier/neurovascular unit in health and disease

BT Hawkins et al.

PHARMACOLOGICAL REVIEWS (2005)

Article Biochemical Research Methods

Microfluidic tools for high-throughput screening

TA Thorsen

BIOTECHNIQUES (2004)

Review Biotechnology & Applied Microbiology

Integration of cell culture and microfabrication technology

TH Park et al.

BIOTECHNOLOGY PROGRESS (2003)

Article Engineering, Electrical & Electronic

Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits

SK Cho et al.

JOURNAL OF MICROELECTROMECHANICAL SYSTEMS (2003)

Article Multidisciplinary Sciences

Microfluidic large-scale integration

T Thorsen et al.

SCIENCE (2002)

Article Biotechnology & Applied Microbiology

Microfluidics - downsizing large-scale biology

P Mitchell

NATURE BIOTECHNOLOGY (2001)