4.7 Article

Amino-Functionalized Polystyrene Nano-Plastics Induce Mitochondria Damage in Human Umbilical Vein Endothelial Cells

期刊

TOXICS
卷 10, 期 5, 页码 -

出版社

MDPI
DOI: 10.3390/toxics10050215

关键词

polystyrene nanoparticles; HUVEC; oxidative stress; mitochondria

资金

  1. Zhejiang Provincial Natural Science Foundation of China [LY21E030011]
  2. Scientific Innovation Program for University Students in Zhejiang Province [2020R403026]

向作者/读者索取更多资源

Nano-plastics, as emerging contaminants, have adverse effects on the ecosystem and human health. This study investigated the biological effects of noncharged polystyrene nano-plastics and amino-functionalized nano-plastics on human umbilical vein endothelial cells. The results showed that the amino-functionalized nano-plastics had higher cytotoxicity and dysregulated mitochondrial function in endothelial cells.
As emerging contaminants, nano-plastics have become a major cause for concern for their adverse effects on the ecosystem and human health. The nano-sized properties of nano-plastics enable their exposure risks to humans through the food chain or other ways. However, the fate and adverse impact of nano-plastics on the human cardiovascular system are lacking. In this regard, the human umbilical vein endothelial cell line HUVEC was applied as a cell model to investigate the biological effects of noncharged polystyrene nano-plastics (PS NPs) and amino-functionalized nano-plastics (NH2-PS NPs). The positively charged PS NPs exhibited higher cytotoxicity to HUVEC, as evidenced by the decreased cell viability, enhanced ROS generation, and decreased mitochondria membrane potential triggered by NH2-PS NPs. Importantly, RT-PCR analysis revealed that NH2-PS NPs dysregulated the mitochondrial dynamics, replication, and function-related gene expression. This study demonstrated that NH2-PS NPs presented higher risks to endothelial cells than noncharged nano-plastics by interfering with mitochondria, which supported the direct evidence and expanded the potential risks of PS NPs.

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