期刊
JOURNAL OF CELL BIOLOGY
卷 214, 期 3, 页码 248-257出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201604085
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资金
- American Association for Cancer Research
- Burroughs Wellcome Fund
- Koch Institute
- Ludwig Center at the Massachusetts Institute of Technology
- Stand Up to Cancer
- National Science Foundation Graduate Research Fellowship
- National Institutes of Health [R21 CA198028]
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells increase serine synthesis from glucose and require de novo serine synthesis even in the presence of abundant extracellular serine. Recent studies cast new light on the role of serine metabolism in cancer, suggesting that active serine synthesis might be required to facilitate amino acid transport, nucleotide synthesis, folate metabolism, and redox homeostasis in a manner that impacts cancer.
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