☆ 4.6 Review

A2 Milk and BCM-7 Peptide as Emerging Parameters of Milk Quality

FRONTIERS IN NUTRITION (2022)

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Review Nutrition & Dietetics

A1-and A2 beta-casein on health-related outcomes: a scoping review of animal studies

Daniela Kuellenberg de Gaudry et al.

Summary: The study reviewed 42 animal studies investigating the effects of A1 beta-casein or BCM-7 compared to A2 beta-casein on health-related outcomes, with only a few studies directly comparing A1 and A2 milk. Most studies focused on the physiological properties of BCM-7 as an opioid peptide. More research in animal models is needed to address the gaps in understanding the effects of different types of beta-casein on health.

EUROPEAN JOURNAL OF NUTRITION (2022)

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Article Chemistry, Applied

β-Casomorphin: A complete health perspective

Muthu Thiruvengadam et al.

Summary: This review provides detailed information on the production process, structural properties, and immunological aspects related to human health of BCM and its derived peptides, allowing readers to judge the pros and cons of BCM themselves. Additionally, possible methods for detecting BCM and future applications are also discussed.

FOOD CHEMISTRY (2021)

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Review Nutrition & Dietetics

Beneficial Effects of Milk Having A2 β-Casein Protein: Myth or Reality?

Sae-In S. Kay et al.

Summary: Diet, particularly the consumption of milk and milk products, plays a significant role in human health. The beta-casein proteins in cow milk, specifically A1 and A2 subvariants, have different effects on various organ systems and health outcomes. While A1 consumption is associated with inflammatory markers and opioid-like responses, A2 consumption is easier to digest and has beneficial effects. Further research is needed to understand the short- and long-term effects of consuming A1 and A2 beta-casein proteins.

JOURNAL OF NUTRITION (2021)

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Review Nutrition & Dietetics

The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes

Amira Kohil et al.

Summary: Type 1 Diabetes Mellitus (T1DM) is a complex autoimmune disease with increasing incidence worldwide. The interplay between genetic and environmental factors contributes to its pathogenesis. The relationship between diet and epigenetics plays a significant role in the development of T1DM.

FRONTIERS IN NUTRITION (2021)

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Review Food Science & Technology

Effect of Protein Genotypes on Physicochemical Properties and Protein Functionality of Bovine Milk: A Review

Nan Gai et al.

Summary: Genetic variants of milk proteins, including caseins and whey proteins, have significant effects on the physicochemical properties and functionality of milk. These variants influence rennet coagulation, acid gel formation, heat stability, emulsion formation, and foaming properties of milk in distinct ways.

FOODS (2021)

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Review Food Science & Technology

Health-related outcomes of genetic polymorphism of bovine β-casein variants: A systematic review of randomised controlled trials

Davor Daniloski et al.

Summary: This systematic review evaluated the health impacts of A1 and A2 genetic variants of bovine I3-casein, with results showing that consumption of A2 I3-casein milk can lead to improved tolerance of milk by reducing gut related discomfort. However, the exact mechanisms and specific beneficiaries are still poorly understood at present.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

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Review Nutrition & Dietetics

Potential Protective Protein Components of Cow's Milk against Certain Tumor Entities

Christian Leischner et al.

Summary: Research on milk has shown its positive impact on both prevention and treatment of various types of cancer, with components like caseins, whey proteins, and milk fat exhibiting anti-tumor or cytotoxic effects. Milk plays a significant role in global dietary health.

NUTRIENTS (2021)

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Article Environmental Sciences

Casomorphins and Gliadorphins Have Diverse Systemic Effects Spanning Gut, Brain and Internal Organs

Keith Bernard Woodford

Summary: Food-derived opioid peptides can have diverse and systemic effects on health by binding to opioid receptors in the gut, brain, and other organs. However, challenges exist in demonstrating these effects due to manifestation delays and the complex role of the microbiome. Modifying risk through reducing intake of opioids in certain foods may be a challenging yet effective nutritional strategy for the future.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Food Science & Technology

Unravelled facets of milk derived opioid peptides: a focus on gut physiology, fractures and obesity

Hajara Aslam et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2020)

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Review Food Science & Technology

Occurrence, biological properties and potential effects on human health of β-casomorphin 7: Current knowledge and concerns

Andrea Summer et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

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Review Microbiology

Insights into the reason of Human-Residential Bifidobacteria (HRB) being the natural inhabitants of the human gut and their potential health-promoting benefits

Chyn Boon Wong et al.

FEMS MICROBIOLOGY REVIEWS (2020)

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Review Biochemistry & Molecular Biology

Role of Bioactive Peptide Sequences in the Potential Impact of Dairy Protein Intake on Metabolic Health

Giovanni Tulipano

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Nutrition & Dietetics

Milk A1 β-casein and health-related outcomes in humans: a systematic review

Daniela Kullenberg de Gaudry et al.

NUTRITION REVIEWS (2019)

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Review Oncology

Casein and Peptides Derived from Casein as Antileukaemic Agents

Edgar Ledesma-Martinez et al.

JOURNAL OF ONCOLOGY (2019)

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Review Endocrinology & Metabolism

Childhood diabetes in India

Sanjay Kalra et al.

ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2018)

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Review Endocrinology & Metabolism

A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes

J. S. J. Chia et al.

NUTRITION & DIABETES (2017)

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Review Nutrition & Dietetics

Systematic Review of the Gastrointestinal Effects of A1 Compared with A2 β-Casein

Simon Brooke-Taylor et al.

ADVANCES IN NUTRITION (2017)

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Review Nutrition & Dietetics

Milk Intolerance, Beta-Casein and Lactose

Sebely Pal et al.

NUTRIENTS (2015)

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Review Food Science & Technology

Formation and Degradation of Beta-casomorphins in Dairy Processing

Duc Doan Nguyen et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2015)

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Review Food Science & Technology

Health-promoting properties of bioactive peptides derived from milk proteins in infant food: a review

Vassilios Raikos et al.

DAIRY SCIENCE & TECHNOLOGY (2014)

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Review Food Science & Technology

Review of the potential health impact of β-casomorphins and related peptides

[Anonymous]

EFSA JOURNAL (2009)

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Review Biotechnology & Applied Microbiology

Polymorphism of bovine beta-casein and its potential effect on human health

Stanislaw Kaminski et al.

JOURNAL OF APPLIED GENETICS (2007)

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Review Food Science & Technology

Health implications of milk containing beta-casein with the A(2) genetic variant

SJ Bell et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2006)

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Review Nutrition & Dietetics

The A2 milk case: a critical review

AS Truswell

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2005)

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Review Pharmacology & Pharmacy

Opioid receptor ligands derived from food proteins

H Teschemacher

CURRENT PHARMACEUTICAL DESIGN (2003)

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