4.7 Editorial Material

HMGB2 holds the key to the senescence-associated secretory phenotype

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JOURNAL OF CELL BIOLOGY
卷 215, 期 3, 页码 297-299

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ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201610044

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  1. MRC [MC_U120085810] Funding Source: UKRI
  2. Medical Research Council [MC_U120085810] Funding Source: Medline
  3. Medical Research Council [MC_U120085810] Funding Source: researchfish

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The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. In this issue, Aird et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201608026) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading.

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