Slip slidin' away of mitosis with CRL2zYG11

The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphase promoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601083) show that the E3 ligase CRL2(zYG11) degrades cyclin B1, allowing mitotic slippage.