期刊
JOURNAL OF CELL BIOLOGY
卷 215, 期 2, 页码 143-145出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201609086
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The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphase promoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601083) show that the E3 ligase CRL2(zYG11) degrades cyclin B1, allowing mitotic slippage.
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