A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17

Damaged mitochondrial content is packaged in mitochondrial-derived vesicles (MDVs), which are targeted for degradation through an unclear mechanism. McLelland et al. (2016. J. Cell Biol. http ://dx. doi. org /10.1083 /jcb.201603105) show that the SNA RE Syntaxin-17 mediates MDV fusion with endolysosomes, promoting the delivery of mitochondrial cargo to lysosomes for degradation.