4.6 Article

Leelamine Modulates STAT5 Pathway Causing Both Autophagy and Apoptosis in Chronic Myelogenous Leukemia Cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives

Srimanta Patra et al.

Summary: Autophagy is a self-degradation process that eliminates dysfunctional cytoplasmic cargos to maintain cellular homeostasis. It plays a dual role in cytoprotection and cytostasis during malignant transformation, and is regulated by phyto-products. Autophagy also regulates epigenetic modulation and inflammation, limiting tumor metastasis.

SEMINARS IN CANCER BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Pyrimethamine Modulates Interplay between Apoptosis and Autophagy in Chronic Myelogenous Leukemia Cells

Young Yun Jung et al.

Summary: The study revealed that pyrimethamine (Pyri) has a significant inhibitory effect on chronic myeloid leukemia (CML), targeting both apoptosis and autophagy cell death mechanisms to suppress tumor cell growth.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells

Mai Shi et al.

CELLULAR SIGNALLING (2019)

Review Biochemistry & Molecular Biology

Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics

Prakash P. Praharaj et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Review Biochemistry & Molecular Biology

A Brief Overview of the Antitumoral Actions of Leelamine

Myriam Merarchi et al.

BIOMEDICINES (2019)

Review Biochemistry & Molecular Biology

The Roles of Autophagy in Cancer

Chul Won Yun et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation

Anuradha Sehrawat et al.

MOLECULAR CARCINOGENESIS (2017)

Article Oncology

Targeting cholesterol transport in circulating melanoma cells to inhibit metastasis

Yu-Chi Chen et al.

PIGMENT CELL & MELANOMA RESEARCH (2017)

Article Rheumatology

Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis

Thibault Bouderlique et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

Review Oncology

Potential of neem (Azadirachta indica L.) for prevention and treatment of oncologic diseases

Shradha M. Patel et al.

SEMINARS IN CANCER BIOLOGY (2016)

Article Multidisciplinary Sciences

Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells

Can Kucuk et al.

NATURE COMMUNICATIONS (2015)

Article Cell Biology

Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer

Sarah R. Walker et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2014)

Article Oncology

Targeting Multiple Key Signaling Pathways in Melanoma Using Leelamine

Raghavendra Gowda et al.

MOLECULAR CANCER THERAPEUTICS (2014)

Article Rheumatology

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

Beatriz Carames et al.

ANNALS OF THE RHEUMATIC DISEASES (2012)

Review Cell Biology

Autophagy in lysosomal storage disorders

Andrew P. Lieberman et al.

AUTOPHAGY (2012)

Article Oncology

Cell-Mediated Autophagy Promotes Cancer Cell Survival

William J. Buchser et al.

CANCER RESEARCH (2012)

Article Cell Biology

Mechanisms and regulation of autophagosome formation

Claudine Kraft et al.

CURRENT OPINION IN CELL BIOLOGY (2012)

Review Oncology

Autophagy and disease: always two sides to a problem

Sunandini Sridhar et al.

JOURNAL OF PATHOLOGY (2012)

Article Gastroenterology & Hepatology

Autophagy inhibition contributes to radiation sensitization of esophageal squamous carcinoma cells

Y. S. Chen et al.

DISEASES OF THE ESOPHAGUS (2011)

Review Oncology

Apoptosis in cancer: from pathogenesis to treatment

Rebecca S. Y. Wong

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2011)

Review Cell Biology

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

Ganta Vijay Chaitanya et al.

CELL COMMUNICATION AND SIGNALING (2010)

Article Cell Biology

Mammalian autophagy: core molecular machinery and signaling regulation

Zhifen Yang et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Apoptosis and autophagy: regulatory connections between two supposedly different processes

Andrew Thorburn

APOPTOSIS (2008)

Review Cell Biology

Autophagy: process and function

Noboru Mizushima

GENES & DEVELOPMENT (2007)

Review Cell Biology

Autophagy: from phenomenology to molecular understanding in less than a decade

Daniel J. Klionsky

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Review Biochemistry & Molecular Biology

STAT5 signaling in normal and pathologic hematopoiesis

Kevin D. Bunting

FRONTIERS IN BIOSCIENCE-LANDMARK (2007)

Review Medicine, General & Internal

New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance

Hagop M. Kantarjian et al.

ANNALS OF INTERNAL MEDICINE (2006)

Review Biochemistry & Molecular Biology

The pleiotropic role of autophagy: from protein metabolism to bactericide

N Mizushima

CELL DEATH AND DIFFERENTIATION (2005)

Review Oncology

Lysosomes and autophagy in cell death control

G Kroemer et al.

NATURE REVIEWS CANCER (2005)

Article Biochemistry & Molecular Biology

Inhibition of macroautophagy triggers apoptosis

P Boya et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells

D Mizuchi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Review Cell Biology

The cell biology of lysosomal storage disorders

AH Futerman et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)

Review Hematology

The biology of CML blast crisis

B Calabretta et al.

Article Biochemistry & Molecular Biology

JAK-STAT signaling activated by Abl oncogenes

NN Danial et al.

ONCOGENE (2000)

Review Oncology

Apoptosis in cancer

SW Lowe et al.

CARCINOGENESIS (2000)