期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2022.911564
关键词
ferroptosis; atherosclerosis; acute myocardial infarction; cardiomyopathy; heart failure
资金
- Hainan Science and Technology Project [ZDYF2020123, ZDYF2020027, ZDKJ2019012]
- Hainan Province Clinical Medical Center, National Key R D Plan [2020YFC2004706]
- National Natural Science Foundation of China [81500202]
Ferroptosis, an iron-dependent regulated cell death, has been shown to be closely related to various cardiovascular diseases. This article reviews the contributions of ferroptosis to cardiovascular diseases and discusses potential strategies for treating these diseases.
Ferroptosis is an iron-dependent regulated cell death characterized by lipid peroxidation and iron overload, which is different from other types of programmed cell death, including apoptosis, necroptosis, autophagy, and pyroptosis. Over the past years, emerging studies have shown a close relation between ferroptosis and various cardiovascular diseases such as atherosclerosis, acute myocardial infarction, ischemia/reperfusion injury, cardiomyopathy, and heart failure. Herein, we will review the contributions of ferroptosis to multiple cardiovascular diseases and the related targets. Further, we discuss the potential ferroptosis-targeting strategies for treating different cardiovascular diseases.
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