期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2022.783426
关键词
myocardial infarction; dioscin; mitochondrial dysfunction; ROS; KREB'S cycle
资金
- National Natural Science Foundation of China [81970414]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [19KJA35000]
This study demonstrates that the natural product dioscin exhibits a protective effect on infarcted hearts by maintaining mitochondrial function, making it a potential therapeutic drug for improving heart function and preventing remodeling in myocardial infarction.
Myocardial infarction is one of the most severe heart diseases, leading to sudden death. Currently, angiography and stenting are widely performed in clinics, yet more effective treatment is still needed. Herein, we presented that dioscin, a natural product, showed protective effect on infarcted hearts via mitochondrial maintenance. Upon dioscin treatment, cardiac dysfunction was alleviated, and remodeling is prevented. Mechanistically, disocin maintains mitochondria function through the maintenance of Kreb's cycle, and suppresion of ROS accumulation. In this way, by targeting mitochondrial dysfunction, dioscin is a potential drug for infarcted hearts.
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