Primary Aldosteronism and Ischemic Heart Disease

Cardiovascular disease, in particular ischemic heart disease is a major cause of morbidity and mortality worldwide. Primary aldosteronism is the leading cause of secondary hypertension, yet commonly under diagnosed, and represents a major preventable risk factor. In contrast to historical teaching, recent studies have shown that excess aldosterone production is associated with increased burden of ischemic heart disease disproportionate to the effects caused by hypertension alone. Aldosterone through its genomic and non-genomic actions exerts various detrimental cardiovascular changes contributing to this elevated risk. Recognition of primary hyperaldosteronism and understanding the distinctive pathophysiology of ischemic heart disease in primary aldosteronism is crucial to develop strategies to improve outcomes.

Automated summary

Cardiovascular disease, especially ischemic heart disease, is a major global cause of illness and death. Primary aldosteronism is the main cause of secondary hypertension, but it is often under-diagnosed. Recent studies have shown that excessive production of aldosterone is associated with an increased risk of ischemic heart disease, which is disproportionate to the effects caused by hypertension alone. Understanding primary hyperaldosteronism and the distinctive pathophysiology of ischemic heart disease in this condition is crucial for improving outcomes.