4.6 Article

Unveiling the Role of DNA Methylation in Vascular CACNA1C Tissue-Specific Expression

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Neurosciences

Vascular calcium signalling and ageing

Osama F. Harraz et al.

Summary: Changes in cellular Ca2+ levels due to vascular ageing can significantly impact vascular function, blood pressure regulation and cardiovascular diseases. Ageing may cause abnormal Ca2+ signalling in SMCs and ECs, leading to dysregulation of vascular tone and blood flow distribution, thereby increasing the risk of cardiovascular diseases. Research on specific ageing-related Ca2+ signalling deficits is crucial to combat accelerated vascular ageing and its associated health risks in an ageing population.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

Article Peripheral Vascular Disease

DNA Methylation-Reprogrammed Ang II (Angiotensin II) Type 1 Receptor-Early Growth Response Gene 1-Protein Kinase C ε Axis Underlies Vascular Hypercontractility in Antenatal Hypoxic Offspring

Ting Xu et al.

Summary: Antenatal hypoxia increases vascular sensitivity to Ang II by upregulating AT1R, leading to activation of the AT1R-Egr1-PKC epsilon axis in vasculature, ultimately predisposing offspring to vascular hypercontractility. This study highlights the impact of adverse antenatal factors on long-term vascular health through reprogrammed gene expression via DNA methylation-mediated epigenetic mechanisms.

HYPERTENSION (2021)

Review Genetics & Heredity

Navigating the DNA methylation landscape of cancer

Atsuya Nishiyama et al.

Summary: DNA methylation is a chemical modification that defines cell type and lineage through controlling gene expression and genome stability. Aberrant DNA methylation in cancer cells targets CpG islands in gene expression regulatory elements. Recent studies suggest that the classical model of DNA hypermethylation in cancer needs to be reevaluated.

TRENDS IN GENETICS (2021)

Article Cell Biology

Prenatal hypoxia inhibited propionate-evoked BK channels of mesenteric artery smooth muscle cells in offspring

Wenna Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Review Biochemistry & Molecular Biology

Tissue-specific adrenergic regulation of the L-type Ca2+ channel Cav1.2

Kwun Nok Mimi Man et al.

SCIENCE SIGNALING (2020)

Review Chemistry, Medicinal

Targeting epigenetics for cancer therapy

Jong Woo Park et al.

ARCHIVES OF PHARMACAL RESEARCH (2019)

Article Cardiac & Cardiovascular Systems

Epigenetics and vascular diseases

Matthew S. Stratton et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)

Article Cardiac & Cardiovascular Systems

Regulation of Blood Pressure by Targeting Ca(V)1.2-Galectin-1 Protein Interaction

Zhenyu Hu et al.

CIRCULATION (2018)

Review Biochemistry & Molecular Biology

DNA Methylation and Histone Modification in Hypertension

Shaunrick Stoll et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Physiology

Calcium- and voltage-gated BK channels in vascular smooth muscle

Alex M. Dopico et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2018)

Article Cell Biology

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

Sadegh Saghafinia et al.

CELL REPORTS (2018)

Article Biochemistry & Molecular Biology

CaV1.2 Channel N-terminal Splice Variants Modulate Functional Surface Expression in Resistance Size Artery Smooth Muscle Cells

John P. Bannister et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Cardiac & Cardiovascular Systems

Mitochondria Control Functional CaV1.2 Expression in Smooth Muscle Cells of Cerebral Arteries

Damodaran Narayanan et al.

CIRCULATION RESEARCH (2010)

Editorial Material Cardiac & Cardiovascular Systems

Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification

Rhian M. Touyz et al.

CARDIOVASCULAR RESEARCH (2009)