期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2021.723332
关键词
remote tissue compression; myocardial infarction; adenosine; A2 receptor; signal transduction; anti-inflammatory
资金
- Jiangsu Leading Talents Project of Traditional Chinese Medicine [SLJ0226]
- Third Open Project of Nursing Advantage Subject in Nanjing University of Chinese Medicine [2019YSHL044, 2019YSHL051]
- National Natural Science Foundation of China [81974583, 81704169]
- Natural Youth Fund Project of Nanjing University of Chinese Medicine [NZY81704169]
This study evaluated the effects of remote tissue compression on infarct size after myocardial infarction and identified its cardioprotective effects. The cardioprotective signal transmission of remote conditioning involves the release of adenosine, essential for its anti-inflammatory properties through the activation of the cAMP/PKA/NF-kappa B axis.
BackgroundRemote ischemic conditioning (RIC) is a cardioprotective phenomenon, yet transient ischemia is not a requisite trigger for remote cardioprotection. In fact, RIC is a stimulus compound containing interruption of the blood vessel and tissue compression. In this study, we evaluate the effects of remote tissue compression on infarct size after myocardial infarction and explore its preliminary mechanisms. Methods and ResultsWe used a murine model of myocardial infarction to assess ischemia injury and identified remote conditioning by rhythmic compression on forelimb as a novel cardioprotective intervention. We show that the cardioprotective signal transduction of remote conditioning from the trigger limb to the heart involves the release of adenosine. Our results demonstrate that A2a and A2b receptors are indispensable parts for cardioprotection of remote conditioning, which is linked to its anti-inflammatory properties by the subsequent activation of cAMP/PKA/NF-kappa B axis. ConclusionOur results establish a new connection between remote tissue compression and cardiovascular diseases, which enhances our cognition about the role of tissue compression on RIC cardioprotection.
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