4.6 Article

Downregulation of Uncoupling Protein 2(UCP2) Mediated by MicroRNA-762 Confers Cardioprotection and Participates in the Regulation of Dynamic Mitochondrial Homeostasis of Dynamin Related Protein1 (DRP1) After Myocardial Infarction in Mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell & Tissue Engineering

Uncoupling protein 2-mediated metabolic adaptations define cardiac cell function in the heart during transition from young to old age

Justin Kurian et al.

Summary: This study reveals a novel role for uncoupling protein 2 (UCP2) in regulating functional properties of cardiac tissue-derived stem-like cells (CTSCs). UCP2, highly expressed in neonatal CTSCs, is linked to glycolysis, proliferation, and survival, but its reduction with age shifts cellular metabolism to oxidative phosphorylation, affecting proliferation and survival in aged CTSCs. Loss of UCP2 in neonatal CTSCs leads to reduced glycolysis, proliferation, and survival, with significant alterations in mitochondrial genes identified by RNA sequencing and bioinformatic analysis.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing

Azadeh Esfandiary et al.

CARDIOVASCULAR RESEARCH (2019)

Review Emergency Medicine

Mechanical, inflammatory, and embolic complications of myocardial infarction: An emergency medicine review

Tim Montrief et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2019)

Review Physiology

Uncoupling Protein 2 in Cardiovascular Health and Disease

Xiao Yu Tian et al.

FRONTIERS IN PHYSIOLOGY (2018)

Review Cell Biology

Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases

Giorgia Pierelli et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Chemistry, Medicinal

UCP2 Modulates Cardioprotective Effects of Ru360 in Isolated Cardiomyocytes during Ischemia

Lukas J. Motloch et al.

PHARMACEUTICALS (2015)

Article Cardiac & Cardiovascular Systems

Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury

Ramiro Zepeda et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long-term Cardiac Dysfunction

Marie-Helene Disatnik et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2013)

Article Cardiac & Cardiovascular Systems

Altered expression of mitochondrial electron transport chain proteins and improved myocardial energetic state during late ischemic preconditioning

Jesus A. Cabrera et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)

Article Pharmacology & Pharmacy

Mechanisms mediating the cardioprotective effects of rapamycin in ischaemia-reperfusion injury

You-Bin Liu et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2011)

Editorial Material Peripheral Vascular Disease

Uncoupling Protein 2 (UCP2): Another Player in the Complex Drama of Vascular Salt Sensitivity

Julian H. Lombard

AMERICAN JOURNAL OF HYPERTENSION (2010)

Article Biotechnology & Applied Microbiology

Interaction between the UCP2-866 G>A polymorphism, diabetes, and β-blocker use among patients with acute coronary syndromes

Amber L. Beitelshees et al.

PHARMACOGENETICS AND GENOMICS (2010)

Article Cardiac & Cardiovascular Systems

The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction

Barry R. Palmer et al.

CARDIOVASCULAR DIABETOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Mitochondrial uncoupling protein 2 mediates temperature heterogeneity in atherosclerotic plaques

Tim J. L. Van de Parre et al.

CARDIOVASCULAR RESEARCH (2008)

Review Medicine, General & Internal

Mechanisms of disease - The failing heart - An engine out of fuel

Stefan Neubauer

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Cardiac & Cardiovascular Systems

Mitochondrial adaptations within chronically ischemic swine myocardium

Edward O. McFalls et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2006)