4.6 Article

CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA

期刊

CELL DEATH DISCOVERY
卷 8, 期 1, 页码 -

出版社

SPRINGERNATURE
DOI: 10.1038/s41420-022-01055-9

关键词

-

资金

  1. National Key Research and Development Program [2018YFC0114705]
  2. Special Foundation for Taishan Scholars [ts20190971]
  3. Natural Science Foundation of China [81874119, 82072912]
  4. Special Support Plan for National High-Level Talents (Ten Thousand Talents Program) [W01020103]
  5. Foundation from Clinical Research Center of Shandong University [2020SDUCRCA015]
  6. Qilu Hospital Clinical New Technology Developing Foundation [2018-7, 2019-3]

向作者/读者索取更多资源

This study identified a novel circRNA, circEIF3H, with significant cancer-promoting function in the progression of TNBC. It acts as a scaffold for IGF2BP2/HuR to regulate mRNA stability. This finding provides a potential target for developing individualized therapy for TNBC.
Triple-negative breast cancer (TNBC) is a molecular subtype with an unfavorable prognosis, and metastasis is the main reason for the failure of clinical treatment. However, the expression profile and regulatory function of circRNAs in TNBC progression are not fully understood. Herein, we performed high-throughput RNA-seq in paired breast cancer tissues and adjacent normal tissues and discovered a novel circRNA, circEIF3H, which was upregulated in breast cancer tissues. Large cohort survival analysis confirmed the association between high circEIF3H expression and poor prognosis of TNBC, indicating the vital function of circEIF3H in TNBC progression. Then we conducted both in vitro and in vivo experiments which illustrated that circEIF3H was essential for TNBC proliferation and metastasis. Further experiments showed that circEIF3H did not function as a microRNA sponge as in the most well-established pathway, but as a scaffold for IGF2BP2 and HuR to regulate the mRNA stability of HSPD1, RBM8A, and G3BP1. Our findings provide insight into a novel circRNA, circEIF3H, with significant cancer-promoting function via serving as a scaffold for IGF2BP2/HuR. These results identified circEIF3H as a potential target for developing individualized therapy of TNBC in the approaching future.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据