4.6 Article

High-dose-androgen-induced autophagic cell death to suppress the Enzalutamide-resistant prostate cancer growth via altering the circRNA-BCL2/miRNA-198/AMBRA1 signaling

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Androgen receptor and MYC equilibration centralizes on developmental super-enhancer

Haiyang Guo et al.

Summary: The androgen receptor in prostate cancer can transcriptionally repress genes like MYC, potentially leading to resistance in response to androgen deprivation or enhanced response to supraphysiological androgen therapy. The interaction between AR and MYC involves coactivator redistribution and disrupts chromatin conformation, impacting gene expression. This intricate balance between AR and MYC highlights their suppressive effects and the potential implications for treatment responses in PCa.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

Emiliano Maiani et al.

Summary: AMBRA1 has been identified as a key regulator in cell cycle control, playing a crucial role in maintaining genomic integrity by regulating the abundance of D-type cyclins and facilitating the transition from G1 to S phase, thereby preventing replication stress. The findings suggest that CHK1 kinase could be a potential therapeutic target in AMBRA1-deficient tumors, highlighting the importance of the AMBRA1-cyclin D pathway in regulating cell cycle and genomic stability in embryonic development and tumorigenesis.

NATURE (2021)

Article Multidisciplinary Sciences

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D

Andrea C. Chaikovsky et al.

Summary: Levels of cyclin D are linked to lung adenocarcinoma development and cellular response to CDK4/6 inhibitors, with AMBRA1 playing a key role in the degradation of cyclin D.

NATURE (2021)

Article Multidisciplinary Sciences

CRL4AMBRA1 is a master regulator of D-type cyclins

Daniele Simoneschi et al.

Summary: The research identifies AMBRA1 as a ubiquitin ligase that degrades D-type cyclins, whose loss leads to accumulation of D-type cyclins and tumorigenesis. Furthermore, AMBRA1 also affects the sensitivity to CDK4/6 inhibitors.

NATURE (2021)

Article Oncology

Cancer treatment and survivorship statistics, 2019

Kimberly D. Miller et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Article Medicine, General & Internal

Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer

Ian D. Davis et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Oncology

Cancer statistics, 2019

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Article Oncology

NCCN Guidelines Updates: Prostate Cancer and Prostate Cancer Early Detection

Peter H. Carroll et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2018)

Article Medicine, General & Internal

Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer

Maha Hussain et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Editorial Material Urology & Nephrology

Extreme Response to High-dose Testosterone in BRCA2-and ATM-mutated Prostate Cancer

Benjamin A. Teply et al.

EUROPEAN UROLOGY (2017)

Article Biochemistry & Molecular Biology

Translation of CircRNAs

Nagarjuna Reddy Pamudurti et al.

MOLECULAR CELL (2017)

Article Biochemistry & Molecular Biology

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

Ivano Legnini et al.

MOLECULAR CELL (2017)

Review Oncology

Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

Philip A. Watson et al.

NATURE REVIEWS CANCER (2015)

Review Oncology

Circular RNA and miR-7 in Cancer

Thomas B. Hansen et al.

CANCER RESEARCH (2013)

Article Multidisciplinary Sciences

Circular RNAs are a large class of animal RNAs with regulatory potency

Sebastian Memczak et al.

NATURE (2013)

Article Medicine, General & Internal

Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy

Charles J. Ryan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Biochemistry & Molecular Biology

Ambra1 at the crossroad between autophagy and cell death

G. M. Fimia et al.

ONCOGENE (2013)

Article Biochemistry & Molecular Biology

Circular RNAs are abundant, conserved, and associated with ALU repeats

William R. Jeck et al.

Article Genetics & Heredity

Circular RNA (circRNA) in Alzheimer's disease (AD)

Walter J. Lukiw

Frontiers in Genetics (2013)

Article Medicine, General & Internal

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

Howard I. Scher et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Editorial Material Biochemistry & Molecular Biology

Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2

Sharon A. Tooze et al.

EMBO JOURNAL (2011)

Review Cell Biology

Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer

Chih-Pin Chuu et al.

JOURNAL OF BIOMEDICAL SCIENCE (2011)

Article Cell Biology

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

Sabrina Di Bartolomeo et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Genetics & Heredity

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

Michael C. Haffner et al.

NATURE GENETICS (2010)

Review Oncology

DNA licensing as a novel androgen receptor mediated therapeutic target for prostate cancer

Jason M. D'Antonio et al.

ENDOCRINE-RELATED CANCER (2009)

Review Urology & Nephrology

CYP17 inhibition as a hormonal strategy for prostate cancer

Alison H. M. Reid et al.

NATURE CLINICAL PRACTICE UROLOGY (2008)

Article Multidisciplinary Sciences

Ambra1 regulates autophagy and development of the nervous system

Gian Maria Fimia et al.

NATURE (2007)

Article Oncology

Rapid androgen cycling as treatment for patients with prostate cancer

David Feltquate et al.

CLINICAL CANCER RESEARCH (2006)

Review Endocrinology & Metabolism

Androgen receptor in prostate cancer

CA Heinlein et al.

ENDOCRINE REVIEWS (2004)

Article Pathology

Relation of Bcl-2 expression to androgen receptor, p21WAF1/CIP1, and cyclin D1 status in prostate cancer

Z Kolár et al.

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY (2000)