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Hippo signaling pathway and respiratory diseases

CELL DEATH DISCOVERY (2022)

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Review Biochemistry & Molecular Biology

Hippo Signaling in Embryogenesis and Development

Zhengming Wu et al.

Summary: The Hippo pathway, known for its role in controlling organ size, also plays diverse functions in development, tissue homeostasis, immunity, and tumorigenesis. It is involved in differential gene expression during embryogenesis and plays a crucial role in tissue specification and organ development during organogenesis.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

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Article Genetics & Heredity

Host genetic effects in pneumonia

Hung-Hsin Chen et al.

Summary: This study identified genetic loci associated with susceptibility and severity of pneumonia, including CFTR locus and HBB locus, which were validated in subsequent studies on COVID-19 hospitalization and lung function. Additionally, a new association in R3HCC1L locus was found in individuals without cystic fibrosis, offering crucial insights into genetic effects influencing the severity of COVID-19 sequelae.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

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Review Medicine, Research & Experimental

The Hippo Pathway in Liver Homeostasis and Pathophysiology

Jordan H. Driskill et al.

Summary: Research on the Hippo pathway has shown its significant role in liver size, regeneration, development, metabolism, and homeostasis, as well as its impact on common liver diseases. Targeting the Hippo pathway pharmacologically may help boost liver regeneration and prevent disease progression.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

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Review Chemistry, Medicinal

Pathological angiogenesis and inflammation in tissues

Ji-Hak Jeong et al.

Summary: The role of angiogenesis in organ and tumor growth is crucial, with vascular-organ interaction being a key mechanism. Vascular endothelial cells are now classified as a type of innate immune cells that are dependent on pathological situations, and inflammatory cytokines and signaling regulators play crucial roles in tissue pathology.

ARCHIVES OF PHARMACAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

Thi Hang Giang Phan et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and typically lethal lung disease with poorly understood mechanisms, involving various cellular processes and molecular pathways. Apoptosis, senescence, epithelial-mesenchymal transition, and other processes have been identified as key factors in tissue remodeling associated with IPF.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Pharmacology & Pharmacy

Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects

Jerold Chun et al.

Summary: Lysophospholipids, particularly sphingosine 1-phosphate (S1P), act through G protein-coupled receptors (GPCRs) and have complex effects on physiological and pathophysiological events. S1PR modulators, including fingolimod, siponimod, and ozanimod, have been approved for multiple sclerosis (MS) treatment, with others like ponesimod and etrasimod in clinical development. These modulators show subtype specificity for S1PRs, influencing downstream effects, and can act as both agonists and functional antagonists.

DRUGS (2021)

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Review Medicine, General & Internal

Pulmonary hypertension in connective tissue diseases, new evidence and challenges

Madelon C. Vonk et al.

Summary: Pulmonary arterial hypertension is a lethal complication of different connective tissue diseases but treatment advancements have mainly benefited patients with idiopathic pulmonary arterial hypertension, while those with connective tissue disease-associated pulmonary arterial hypertension still face challenges. Current research focuses on improving early diagnostic, screening, and treatment options.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Medicine, Research & Experimental

YAP and Wnt3a independently promote AECIIs proliferation and differentiation by increasing nuclear β-catenin expression in experimental bronchopulmonary dysplasia

Xianxian Jia et al.

Summary: The study found that YAP and Wnt3a independently promote proliferation and differentiation of AECII in experimental BPD by increasing nuclear beta-catenin levels.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Review Oncology

YAP and endothelin-1 signaling: an emerging alliance in cancer

Piera Tocci et al.

Summary: Recent studies have shown the interaction between ET-1 and the Hippo pathway, and the ET-1R/beta-arr1 axis triggers a transcriptional interplay involving YAP and mutant p53 proteins, which function in the oncogenic signaling network. Dual ET-1 receptor antagonists can interfere with the ET-1R/YAP/mutp53 signaling interplay, hindering metastasis and therapy resistance in tumors.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Medicine, Research & Experimental

Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea

Shingo Yasuda et al.

Summary: Injury-induced TGF beta 1 upregulation increases S1P generation through SPK1 activity, stimulating the S1PR3-linked signaling pathway and leading to elevated VEGF-A expression levels and enhanced angiogenesis in mouse corneas.

LABORATORY INVESTIGATION (2021)

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Article Oncology

Astragaloside IV attenuates hypoxia-induced pulmonary vascular remodeling via the Notch signaling pathway

Jiamei Yao et al.

Summary: The study investigated the protective effects and mechanisms underlying AS-IV on hypoxia-induced PASMC proliferation and pulmonary vascular remodeling in PAH model rats. AS-IV treatment inhibited hypoxia-induced PASMC proliferation by downregulating PCNA expression and effectively alleviated PAH symptoms by suppressing Notch signaling pathway activity.

MOLECULAR MEDICINE REPORTS (2021)

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Article Multidisciplinary Sciences

Single-cell transcriptomic analysis reveals the immune landscape of lung in steroid-resistant asthma exacerbation

Lingli Wang et al.

Summary: The study identified key immune cells and pathways involved in asthma exacerbation by establishing a mouse model of LPS-induced steroid-resistant exacerbation on the background of house dust mite-induced asthma. This provides important mechanistic insights for further understanding immune responses during asthma exacerbation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Cell & Tissue Engineering

Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

Liyang Dong et al.

Summary: Hypoxic human umbilical cord MSC-derived EVs attenuated allergic airway inflammation and airway remodeling in chronic asthma mice, potentially offering new avenues for asthma treatment.

STEM CELL RESEARCH & THERAPY (2021)

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Article Biochemistry & Molecular Biology

The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis

Pengfei Liu et al.

Summary: This study identifies long noncoding RNA LOC344887 as a novel anti-fibrotic NRF2 target gene which contributes to the antifibrotic potential of NRF2 activator sulforaphane (SFN). LOC344887 controls genes and signaling pathways associated with fibrogenesis, repressing the expression of CDH2 and other fibrotic genes. NRF2-mediated LOC344887 upregulation presents a novel therapeutic axis for prevention and intervention of fibrosis-related diseases.

REDOX BIOLOGY (2021)

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Review Cell Biology

Hippo Signaling Pathway in Gliomas

Konstantin Masliantsev et al.

Summary: The Hippo signaling pathway regulates organ size through cell proliferation and apoptosis, and has been shown to play a role in tumorigenesis and metastasis. Further investigation is needed to understand the role of this pathway in brain tumors and other malignant neoplasms.

CELLS (2021)

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Article Cardiac & Cardiovascular Systems

SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation

Natalie M. Landry et al.

Summary: The study explores the regulatory role of SKI in cardiac fibroblast activation and its interaction with the TAZ protein, shedding light on the unique physiology of cardiac fibroblasts and the relationship between SKI expression and cell phenotype. The findings indicate that SKI's ability to modulate cardiac fibroblast activation is partially mediated by Hippo signaling pathways, highlighting the complex network involved in fibrotic processes in the heart.

BASIC RESEARCH IN CARDIOLOGY (2021)

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Review Nanoscience & Nanotechnology

Nanomedicine-Based Therapeutics to Combat Acute Lung Injury

Shuai Bian et al.

Summary: ALI and ARDS can cause life-threatening respiratory failure with a high mortality rate. Despite some clinical interventions, there is still no completely effective treatment for ALI. Recent advances in nanotechnology may provide new possibilities for the pharmacotherapy of ALI.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

YAP/Hippo Pathway and Cancer Immunity: It Takes Two to Tango

Dimitrios Matthaios et al.

Summary: The YAP and Hippo pathway play crucial roles in immune system and cancer, with effects such as modulating immune response, enhancing tumor microenvironment, and regulating immune suppression, suggesting their potential applications in cancer immunotherapy.

BIOMEDICINES (2021)

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Article Pharmacology & Pharmacy

Luteolin Ameliorates Experimental Pulmonary Arterial Hypertension via Suppressing Hippo-YAP/PI3K/AKT Signaling Pathway

Wanyun Zuo et al.

Summary: In this study, luteolin was found to have a beneficial effect on pulmonary arterial hypertension, possibly through inhibiting the HIPPO-YAP/PI3K/AKT signaling pathway. Therefore, luteolin may become a promising candidate for the treatment of PAH.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma

Priyanka Banerjee et al.

Summary: In this study, the regulatory relationship between ASM genes in asthma patients was explored, revealing a loss of gene connectivity in asthmatic ASM due to the rewiring of major regulators. Transcription factors and differentially correlated genes in asthmatic ASM were identified, potentially modulating gene expression. Moreover, genes involved in pathways such as herpes simplex virus infection, Hippo and TGF-beta signaling were over-represented in asthmatic ASM.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids

Md Soriful Islam et al.

Summary: Injections of collagenase into uterine fibroids led to a reduction in stiffness, inhibited cell growth, and decreased key factors promoting fibroid growth. Inhibition of YAP signaling pathway showed promising effects in suppressing cell proliferation and fibrosis-related pathways in fibroid cells, suggesting a potential therapeutic strategy for uterine fibroids.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

Stephanie Z. Xie et al.

Summary: The study reveals the important regulatory role of S1PR3 in AML patients, promoting myeloid differentiation and activating inflammatory programs, showing a continuous variation from primitive to mature myeloid states. This finding opens new avenues for specific therapeutic target identification in different AML subsets.

BLOOD CANCER DISCOVERY (2021)

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Article Biochemistry & Molecular Biology

S1P induces proliferation of pulmonary artery smooth muscle cells by promoting YAP-induced Notch3 expression and activation

Jian Wang et al.

Summary: S1P promotes PASMC proliferation by activating the S1PR2/STAT3/miR-135b/beta-transduction repeat-containing protein/YAP/Notch3 pathway.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Review Physiology

Pulmonary arterial hypertension and flavonoids: A role in treatment

Jialing Wang et al.

Summary: Flavonoids are a class of compounds widely distributed in nature, with diverse biological activities and pharmacological effects that can be used to treat PAH. This review summarizes the progress of flavonoids in the treatment of PAH in recent years, providing theoretical references for relevant research.

CHINESE JOURNAL OF PHYSIOLOGY (2021)

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Article Oncology

Efficacy of YAP1-gene Knockdown to Inhibit Alveolar-Epithelial-Cell Senescence and Alleviate Idiopathic Pulmonary Fibrosis (IPF)

Wei Xu et al.

Summary: The study showed that knocking down the YAP1 gene can inhibit the senescence of AECs and alleviate the severity of IPF in a mouse model. This suggests that inhibiting YAP1 expression may be a potential therapeutic strategy for IPF in the future.

CANCER GENOMICS & PROTEOMICS (2021)

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Review Biochemistry & Molecular Biology

The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis

Mohammad Reza Zinatizadeh et al.

Summary: Hippo tumor suppressor pathway regulates cell growth and affects tumor progression, with MST kinases activating AGC kinase dmWts or LATS effector, and YAP as a cofactor for transcription factors. Loss of Hippo pathway may have significant consequences on RAS-RAF mutations in cancer.

GENES & DISEASES (2021)

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Article Respiratory System

Effect of asthma and asthma medication on the prognosis of patients with COVID-19

Yong Jun Choi et al.

Summary: The study found that asthma patients with COVID-19 had a significantly higher mortality rate than other patients, but asthma was not an independent risk factor for the clinical outcomes of COVID-19. Furthermore, asthma medication use and asthma severity did not affect the clinical outcomes of COVID-19.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Oncology

let7f-5p attenuates inflammatory injury in in vitro pneumonia models by targeting MAPK6

Lin Xu et al.

Summary: This study found that let7f-5p plays a role in inhibiting inflammation in pneumonia, potentially serving as a novel therapeutic target.

MOLECULAR MEDICINE REPORTS (2021)

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Review Pharmacology & Pharmacy

Essential Role of Pharmacists in Asthma Care and Management

Mary B. Bridgeman et al.

Summary: Asthma, a chronic respiratory disease with complex treatment challenges, requires more effective therapeutic approaches due to poor medication adherence. Pharmacists play a key role in the care of asthma patients by providing education, training, addressing concerns, and improving adherence to therapy.

JOURNAL OF PHARMACY PRACTICE (2021)

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Review Cell Biology

Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration

Michael A. Flinn et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis

Daniela M. Santos et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

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Article Oncology

YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators

Sany Hoxha et al.

CANCER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

Yingchuan Li et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Review Microbiology

The Hippo Pathway and Viral Infections

Zhilong Wang et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Mechanisms of ATII-to-ATI Cell Differentiation during Lung Regeneration

Mohit Aspal et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Immunology

The Crosstalk Between Hippo-YAP Pathway and Innate Immunity

Shuai Wang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System

Jinbo Cheng et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Angiomotin regulates budding and spread of Ebola virus

Ziying Han et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Article Cell Biology

Metformin suppresses proliferation and invasion of drug-resistant breast cancer cells by activation of the Hippo pathway

Jie Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Chemistry, Multidisciplinary

Mechanical Cues Regulating Proangiogenic Potential of Human Mesenchymal Stem Cells through YAP-Mediated Mechanosensing

Praveen Bandaru et al.

SMALL (2020)

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Article Biology

STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism

Sung Jun Bae et al.

ELIFE (2020)

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Review Cell Biology

Integration of Hippo-YAP Signaling with Metabolism

Consuelo Ibar et al.

DEVELOPMENTAL CELL (2020)

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Article Multidisciplinary Sciences

A CTGF-YAP Regulatory Pathway Is Essential for Angiogenesis and Barriergenesis in the Retina

Sohyun Moon et al.

ISCIENCE (2020)

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Article Cell Biology

Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair

Qian Chen et al.

CELL REPORTS (2020)

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Article Immunology

A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma

Hani Harb et al.

NATURE IMMUNOLOGY (2020)

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Editorial Material Immunology

Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma

Hamida Hammad et al.

NATURE IMMUNOLOGY (2020)

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Article Cell Biology

Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury

Kun Xiao et al.

CELL DEATH & DISEASE (2020)

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Review Cell Biology

Emerging role of the Hippo pathway in autophagy

Dongying Wang et al.

CELL DEATH & DISEASE (2020)

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Review Oncology

Interaction of the Hippo Pathway and Phosphatases in Tumorigenesis

Sahar Sarmasti Emami et al.

CANCERS (2020)

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Article Oncology

Mutant Proteomics of Lung Adenocarcinomas Harboring DifferentEGFRMutations

Toshihide Nishimura et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Cell Biology

Hypoxia-Inducible Factor-1: A Potential Target to Treat Acute Lung Injury

Yang Liu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Immunology

YAP Deficiency Attenuates Pulmonary Injury Following Mechanical Ventilation Through the Regulation of M1/M2 Macrophage Polarization

Qiong Luo et al.

JOURNAL OF INFLAMMATION RESEARCH (2020)

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Review Medicine, Research & Experimental

Autophagy markers as mediators of lung injury-implication for therapeutic intervention

Selvaraj Vishnupriya et al.

LIFE SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Endothelial YAP1 in Regenerative Lung Growth through the Angiopoietin-Tie2 Pathway

Tadanori Mammoto et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Developmental pathways in the pathogenesis of lung fibrosis

Diptiman Chanda et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

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Article Medicine, Research & Experimental

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation

Ryan LaCanna et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Biochemistry & Molecular Biology

Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice

Katarzyna O. Rojek et al.

PLOS BIOLOGY (2019)

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Review Cell Biology

Hippo Pathway in Mammalian Adaptive Immune System

Takayoshi Yamauchi et al.

CELLS (2019)

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Review Cell Biology

Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis

Gandhi T. K. Boopathy et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

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Review Cell Biology

The Hippo Signaling Pathway in Development and Disease

Yonggang Zheng et al.

DEVELOPMENTAL CELL (2019)

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Article Multidisciplinary Sciences

Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction

Antonio Totaro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Biochemistry & Molecular Biology

Control of cellular responses to mechanical cues through YAP/TAZ regulation

Ishani Dasgupta et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Cell Biology

Lats2-Underexpressing Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice

Liang Dong et al.

MEDIATORS OF INFLAMMATION (2019)

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Review Biochemistry & Molecular Biology

The Hippo Pathway: Biology and Pathophysiology

Shenghong Ma et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

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Article Physiology

Upregulation of LncRNA Malat1 Induced Proliferation and Migration of Airway Smooth Muscle Cells via miR-150-eIF4E/Akt Signaling

Li Lin et al.

FRONTIERS IN PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

YAP1/Twist promotes fibroblast activation and lung fibrosis that conferred by miR-15a loss in IPF

Yingzhun Chen et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Medicine, General & Internal

S1P/S1PR3 axis promotes aerobic glycolysis by YAP/c-MYC/PGAM1 axis in osteosarcoma

Yifei Shen et al.

EBIOMEDICINE (2019)

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Article Cell Biology

Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif

Thi Hai Yen Tran et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2019)

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Review Oncology

YAP/TAZ Signaling and Resistance to Cancer Therapy

Chan D. K. Nguyen et al.

TRENDS IN CANCER (2019)

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Article Medicine, Research & Experimental

Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis

Siyi Li et al.

THERANOSTICS (2019)

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Article Oncology

Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence

Cong Zhang et al.

ONCOTARGET (2018)

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Article Physiology

Sphingosine-1-phosphate induces airway smooth muscle cell proliferation, migration, and contraction by modulating Hippo signaling effector YAP

Lu Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

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Article Oncology

SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin-Rho GTPase-Hippo Pathways

Yan-Li Zhang et al.

CANCER RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway

Xiaoguang Zhao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Medicine, Research & Experimental

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis

Beiyun Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article

Loss of KIBRA function activates EGFR signaling by inducing AREG

Ashley L. Mussell et al.

Oncotarget (2018)

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Review Oncology

The Hippo Pathway: Immunity and Cancer

Zaid Taha et al.

CANCERS (2018)

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Review Genetics & Heredity

The Hippo Signaling Network and Its Biological Functions

Jyoti R. Misra et al.

ANNUAL REVIEW OF GENETICS, VOL 52 (2018)

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Article Medicine, Research & Experimental

miRNA-1246 suppresses acute lung injury-induced inflammation and apoptosis via the NF-κB and Wnt/β-catenin signal pathways

Tao Suo et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inFLammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway

MinJie Ju et al.

CELL CYCLE (2018)

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Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling

Sebastian Mana-Capelli et al.

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RAP2 mediates mechanoresponses of the Hippo pathway

Zhipeng Meng et al.

NATURE (2018)

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Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury

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Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation

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YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer

Satoshi Noguchi et al.

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The role of Hippo/yes-associated protein signalling in vascular remodelling associated with cardiovascular disease

Jinlong He et al.

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Active epithelial Hippo signaling in idiopathic pulmonary fibrosis

Jason J. Gokey et al.

JCI INSIGHT (2018)

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Biomarkers in Pediatric Community-Acquired Pneumonia

Nicola Principi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Biochemistry & Molecular Biology

The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics

Kristin Meliambro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Investigation of the Possible Role of the Hippo/YAP1 Pathway in Asthma and Allergy

Lili E. Fodor et al.

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Regulation of localization and function of the transcriptional co-activator YAP by angiomotin

Susana Moleirinho et al.

ELIFE (2017)

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Prediction of target genes for miR-140-5p in pulmonary arterial hypertension using bioinformatics methods

Fangwei Li et al.

FEBS OPEN BIO (2017)

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DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins

Hung Thanh Nguyen et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort

Joshua S. Davis et al.

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Article Cell Biology

Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells

Thomas Volckaert et al.

DEVELOPMENTAL CELL (2017)

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Review Biochemistry & Molecular Biology

The role of extracellular biophysical cues in modulating the Hippo-YAP pathway

Jung-Soon Mo

BMB REPORTS (2017)

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Article Oncology

Verteporfin suppresses cell survival, angiogenesis and vasculogenic mimicry of pancreatic ductal adenocarcinoma via disrupting the YAP-TEAD complex

Honglong Wei et al.

CANCER SCIENCE (2017)

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Article Critical Care Medicine

HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension

Tatiana V. Kudryashova et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

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Review Cell Biology

Mechanisms of Hippo pathway regulation

Zhipeng Meng et al.

GENES & DEVELOPMENT (2016)

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Review Gastroenterology & Hepatology

The Hippo pathway in intestinal regeneration and disease

Audrey W. Hong et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

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Article Medicine, Research & Experimental

Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis

Yan Xu et al.

JCI INSIGHT (2016)

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Review Physiology

Hippo and TGF-β interplay in the lung field

Akira Saito et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

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Article Physiology

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Fei Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

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Review Biochemistry & Molecular Biology

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

Fa-Xing Yu et al.

CELL (2015)

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Article Cell Biology

Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway

Nam-Gyun Kim et al.

JOURNAL OF CELL BIOLOGY (2015)

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Article Cell Biology

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

Jung-Soo Mo et al.

NATURE CELL BIOLOGY (2015)

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Article Cell Biology

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung

Alexander W. Lange et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2015)

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Review Cell Biology

KIBRA: In the brain and beyond

Lin Zhang et al.

CELLULAR SIGNALLING (2014)

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Article Gastroenterology & Hepatology

STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer

Andrew V. Nguyen et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Article Biochemistry & Molecular Biology

Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos

Yoshikazu Hirate et al.

CURRENT BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Fa-Xing Yu et al.

CELL (2012)

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