MicroRNA-31: a pivotal oncogenic factor in oral squamous cell carcinoma

Article Oncology

M2 macrophage-derived exosomes promote lung adenocarcinoma progression by delivering miR-942

Ke Wei et al.

Summary: The study demonstrates that exosomes derived from M2 macrophages play a role in promoting invasion and migration of LUAD cells through miRNA regulation, providing a new therapeutic target for metastatic LUAD.

CANCER LETTERS (2022)

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Article Endocrinology & Metabolism

Downregulation of miR-216a-5p and miR-652-3p is associated with growth and invasion by targeting JAK2 and PRRX1 in GH-producing pituitary tumours

Yang Jong Lee et al.

Summary: This study investigated the role of miRNA expression during the tumorigenesis of growth hormone (GH)-secreting pituitary tumours. The study found that miR-216a-5p and miR-652-3p expression played a significant role in tumor progression by targeting JAK2 and PRRX1, which promoted tumor proliferation and invasion.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2022)

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Article Dentistry, Oral Surgery & Medicine

Extracellular vesicles miR-210 as a potential biomarker for diagnosis and survival prediction of oral squamous cell carcinoma patients

Elisabetta Bigagli et al.

Summary: The expression of EV-miR-210 is significantly elevated in OSCC patients, showing potential as a diagnostic biomarker with high sensitivity and specificity. High EV-miR-210 expression is associated with worse 3-year survival, along with G2 and G3 grading and pN status being independent predictors of poor survival in OSCC patients.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2022)

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Article Genetics & Heredity

The prognostic role of miR-31 in colorectal cancer: the results of a meta-analysis of 4720 patients

Milad Moloudizargari et al.

Summary: High miR-31 expression is associated with poor overall survival and progression-free survival in colorectal cancer patients, with a significant predictive value for anti-EGFR response. High expressers are more likely to have a BRAF mutation, and the observed associations are significantly affected by therapeutic regimen and mutational status.

EPIGENOMICS (2022)

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Article Biochemistry & Molecular Biology

miR-31-NUMB Cascade Modulates Monocarboxylate Transporters to Increase Oncogenicity and Lactate Production of Oral Carcinoma Cells

Chung-Hsien Chou et al.

Summary: Oral squamous cell carcinoma (OSCC) is a major cause of cancer-related deaths globally, with miR-31 playing an oncogenic role in OSCC. The study highlights the disruption of the miR-31-NUMB regulatory axis in malignancies, specifically leading to changes in glycolysis and upregulation of MCT1 and MCT4 as prognostic factors in OSCC. Additionally, the research reveals that NUMB4 binds to MCT1 and MCT4, increasing their ubiquitination and potentially reducing their abundance in cell lysates. This study demonstrates the significance of NUMB as a novel binding partner for MCT1 and MCT4, and the regulatory cascade involving miR-31-NUMB-MCT1/MCT4 in oral carcinoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis

Cheng-Peng Gui et al.

Summary: The study identified circCHST15 as a potential prognostic biomarker and therapeutic target for ccRCC, demonstrating its role in promoting proliferation, migration, and invasion of ccRCC cells by sponging miR-125a-5p to regulate EIF4EBP1 expression. CircCHST15 was found to be highly expressed in ccRCC tissues and cell lines, correlating with aggressive clinicopathological characteristics and serving as an independent prognostic indicator for overall survival and progression-free survival in patients with ccRCC after surgical resection. The study suggests further investigation of circCHST15 for its clinical implications in ccRCC management.

MOLECULAR CANCER (2021)

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Review Dentistry, Oral Surgery & Medicine

The role of differentially expressed salivary microRNA in oral squamous cell carcinoma. A systematic review

Natheer Al Rawi et al.

Summary: This systematic review identified differentially expressed miRNAs in saliva of oral cancer patients that could potentially serve as biomarkers for diagnosis and prognosis of oral squamous cell carcinoma (OSCC). However, further controlled clinical trials with large sample sizes are needed to validate these findings.

ARCHIVES OF ORAL BIOLOGY (2021)

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Article Oncology

MiRNA-146a/AKT/β-Catenin Activation Regulates Cancer Stem Cell Phenotype in Oral Squamous Cell Carcinoma by Targeting CD24

Sangeeta Ghuwalewala et al.

Summary: The study found an elevated expression of miR-146a in the CD44(high)CD24(low) population within OSCC cells and primary HNSCC tumors. Over-expression of miR-146a enhances stemness phenotype by stabilizing beta-catenin and resulting in loss of E-cadherin and CD24. CD24 is identified as a novel functional target of miR-146a, and mechanistic analysis reveals that higher CD24 levels inhibit AKT phosphorylation leading to beta-catenin degradation.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

Extracellular vesicles derived from radioresistant oral squamous cell carcinoma cells contribute to the acquisition of radioresistance via the miR-503-3p-BAK axis

Keisuke Yamana et al.

Summary: Despite advancements in treatments, oral squamous cell carcinoma (OSCC) has not significantly improved in prognosis or survival rate primarily due to the presence of treatment-resistant OSCC. The intercellular communication between tumour cells is a molecular mechanism involved in acquiring OSCC treatment resistance. Extracellular vesicles (EVs) and encapsulated miRNAs are important mediators of intercellular communication. Our results provide new insights into the relationship between EVs and the radioresistance of OSCC and suggest that the miR-503-3p-BAK axis may be a therapeutic target and that circulating miR-503-3p is a useful prognostic biomarker in the radiotherapy of OSCC.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Oncology

Hypoxic tumor-derived exosomal miR-31-5p promotes lung adenocarcinoma metastasis by negatively regulating SATB2-reversed EMT and activating MEK/ERK signaling

Fengqiang Yu et al.

Summary: Exosomal miR-31-5p derived from hypoxic LUAD cells plays a crucial role in promoting tumor progression by targeting specific genes and signaling pathways. Higher levels of circulating exosomal miR-31-5p were detected in LUAD patients, particularly those with metastatic disease, suggesting its potential as a diagnostic biomarker for LUAD.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C/EBPβ-mediated PDGFB autocrine and paracrine signaling

Shangce Du et al.

Summary: Anoikis resistance is crucial for the survival of metastatic cancer cells, but the molecular mechanisms are poorly understood. Study found that GC(AR) cells exhibit stronger metastatic and pro-angiogenic traits, promoting GC cell survival and angiogenesis through elevated PDGFB secretion.

ONCOGENE (2021)

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Article Nanoscience & Nanotechnology

Macrophage-Derived Exosomal miR-31-5p Promotes Oral Squamous Cell Carcinoma Tumourigenesis Through the Large Tumor Suppressor 2-Mediated Hippo Signalling Pathway

Yi Yuan et al.

Summary: This study showed that M2 macrophage-derived exosomal miR31-5p can inhibit the tumor suppressor LATS2 gene and promote OSCC progression by suppressing the Hippo signaling pathway, potentially providing new targets for molecular therapy of OSCC.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Article Cell Biology

circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway

Qiu-Shi Peng et al.

CELL DEATH & DISEASE (2020)

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Article Pharmacology & Pharmacy

WNT7A Promotes EGF-Induced Migration of Oral Squamous Cell Carcinoma Cells by Activating beta-Catenin/MMP9-Mediated Signaling

Hui Xie et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Colorectal Adenomas-Genetics and Searching for New Molecular Screening Biomarkers

Anna Siskova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

Glucose Metabolism and Oxidative Stress in Hepatocellular Carcinoma: Role and Possible Implications in Novel Therapeutic Strategies

Monica Mossenta et al.

CANCERS (2020)

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Article Biochemistry & Molecular Biology

MicroRNA-31 Regulates Expression of Wntless in Both Drosophila melanogaster and Human Oral Cancer Cells

Ji Eun Jung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Oncology

Long non-coding RNA CASC2 enhances cisplatin sensitivity in oral squamous cell cancer cells by the miR-31-5p/KANK1 axis

J. Wang et al.

NEOPLASMA (2020)

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Article Clinical Neurology

Inhibition of glioblastoma cell invasion by hsa-miR-145-5p and hsa-miR-31-5p co-overexpression in human mesenchymal stem cells

Ryota Kurogi et al.

JOURNAL OF NEUROSURGERY (2019)

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Article Oncology

miR-31-3p Expression and Benefit from Anti-EGFR Inhibitors in Metastatic Colorectal Cancer Patients Enrolled in the Prospective Phase II PROSPECT-C Trial

Gayathri Anandappa et al.

CLINICAL CANCER RESEARCH (2019)

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Article Otorhinolaryngology

MicroRNA expression patterns in oral squamous cell carcinoma: hsa-mir-99b-3p and hsa-mir-100-5p as novel prognostic markers for oral cancer

Mark Jakob et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2019)

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Article Biochemistry & Molecular Biology

Long noncoding RNA FOXD2-AS1 promotes glioma cell cycle progression and proliferation through the FOXD2-AS1/miR-31/CDK1 pathway

Jin Wang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Oncology

MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma

Yu-Yu Kao et al.

CANCER LETTERS (2019)

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Article Oncology

FOXC1 Regulation of miR-31-5p Confers Oxaliplatin Resistance by Targeting LATS2 in Colorectal Cancer

Hsi-Hsien Hsu et al.

CANCERS (2019)

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Review Cell Biology

New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer

Anushka Dongre et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Article Oncology

Predicting the Presence of Oral Squamous Cell Carcinoma Using Commonly Dysregulated MicroRNA in Oral Swirls

Tami Yap et al.

CANCER PREVENTION RESEARCH (2018)

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Article Medicine, Research & Experimental

MiR-31-5p-ACOX1 Axis Enhances Tumorigenic Fitness in Oral Squamous Cell Carcinoma Via the Promigratory Prostaglandin E2

Yi-Hsuan Lai et al.

THERANOSTICS (2018)

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Review Immunology

Relationship between type of smokeless tobacco & risk of cancer: A systematic review

Sanjay Gupta et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2018)

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Review Medicine, Research & Experimental

Functions and mechanisms of microRNA-31 in human cancers

Tao Yu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Cell Biology

Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma

Zhong-Yi Yan et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

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Article Otorhinolaryngology

Comparison of microRNA profiles between benign and malignant salivary gland tumors in tissue, blood and saliva samples: a prospective, case-control study

Ovgu Cinpolat et al.

BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY (2017)

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Review Biochemistry & Molecular Biology

Molecular mechanisms of ovarian carcinoma metastasis: Key genes and regulatory microRNAs

E. A. Braga et al.

BIOCHEMISTRY-MOSCOW (2017)

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Article Genetics & Heredity

MiR-31 inhibits migration and invasion by targeting SATB2 in triple negative breast cancer

Long-ji Luo et al.

GENE (2016)

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Review Biochemistry & Molecular Biology

Function and Regulation of MicroRNA-31 in Development and Disease

Nadezda A. Stepicheva et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2016)

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Article Oncology

Downregulated miR-31 level associates with poor prognosis of gastric cancer and its restoration suppresses tumor cell malignant phenotypes by inhibiting E2F2

Huaidong Wang et al.

ONCOTARGET (2016)

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Article Genetics & Heredity

Small RNAs in metastatic and non-metastatic oral squamous cell carcinoma

Patricia Severino et al.

BMC MEDICAL GENOMICS (2015)

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Article Oncology

The increase of oncogenic miRNA expression in tongue carcinogenesis of a mouse model

Yu-Yu Kao et al.

ORAL ONCOLOGY (2015)

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Article Multidisciplinary Sciences

Similar Squamous Cell Carcinoma Epithelium microRNA Expression in Never Smokers and Ever Smokers

Antonia Kolokythas et al.

PLOS ONE (2015)

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Article Oncology

miR-31 is upregulated in oral premalignant epithelium and contributes to the immortalization of normal oral keratinocytes

Pei-Shih Hung et al.

CARCINOGENESIS (2014)

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Article Oncology

Effects of activated fibroblasts on phenotype modulation, EGFR signalling and cell cycle regulation in OSCC cells

Alexander Berndt et al.

EXPERIMENTAL CELL RESEARCH (2014)

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Review Cell Biology

Regulation of microRNA biogenesis

Minju Ha et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Article Dentistry, Oral Surgery & Medicine

Dysregulation of miR-31 and miR-375 expression is associated with clinical outcomes in oral carcinoma

M. Y. Siow et al.

ORAL DISEASES (2014)

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Article Multidisciplinary Sciences

EGF Up-Regulates miR-31 through the C/EBPβ Signal Cascade in Oral Carcinoma

Wen-Cheng Lu et al.

PLOS ONE (2014)

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Review Oncology

The Diverse Role of miR-31 in Regulating Cancer Associated Phenotypes

Eeva M. Laurila et al.

GENES CHROMOSOMES & CANCER (2013)

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Article Oncology

Passenger strand miRNA miR-31* regulates the phenotypes of oral cancer cells by targeting RhoA

Kuo-Wei Chang et al.

ORAL ONCOLOGY (2013)

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Article Otorhinolaryngology

Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma

Chung-Ji Liu et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2012)

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Article Medicine, Research & Experimental

The oncogenetic role of microRNA-31 as a potential biomarker in oesophageal squamous cell carcinoma

Tengfei Zhang et al.

CLINICAL SCIENCE (2011)

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Review Oncology

Perineural invasion in oral squamous cell carcinoma: A discussion of significance and review of the literature

Nada O. Binmadi et al.

ORAL ONCOLOGY (2011)

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Article Oncology

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

Ana-Maria Florea et al.

Cancers (2011)

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Review Cell Biology

miR-31 A crucial overseer of tumor metastasis and other emerging roles

Scott Valastyan et al.

CELL CYCLE (2010)

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Article Dentistry, Oral Surgery & Medicine

Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer

C-J Liu et al.

ORAL DISEASES (2010)

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Article Oncology

Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer

O. Slaby et al.

ONCOLOGY (2007)

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MicroRNA-31: a pivotal oncogenic factor in oral squamous cell carcinoma

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