4.6 Article

Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents

Elena Cichero et al.

Summary: Targeting the fusion (F) protein is a recognized strategy for developing anti-RSV agents, with benzimidazole-containing derivatives showing promise in clinical trials. Computational studies based on X-ray crystallographic data of RSV F protein revealed key contacts supporting the benzimidazole F protein inhibitor ability. The results emphasized the importance of hydrophobic interactions, pi-pi stacking, and H-bonding in the binding ability of benzimidazole F protein inhibitors.

PHARMACEUTICALS (2021)

Article Biochemistry & Molecular Biology

Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors

Giada Righetti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Physiology

STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL

Laszlo Csanady et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Biochemistry & Molecular Biology

Structure-guided combination therapy to potently improve the function of mutant CFTRs

Guido Veit et al.

NATURE MEDICINE (2018)

Article Medicine, General & Internal

VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

Dominic Keating et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

J. C. Davies et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Molecular structure of the ATP-bound, phosphorylated human CFTR

Zhe Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Medicine, General & Internal

New treatments targeting the basic defects in cystic fibrosis

Isabelle Fajac et al.

PRESSE MEDICALE (2017)

Review Medicine, General & Internal

Cystic fibrosis

J. Stuart Elborn

LANCET (2016)

Article Medicine, General & Internal

Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

C. E. Wainwright et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Genetics & Heredity

Cystic fibrosis genetics: from molecular understanding to clinical application

Garry R. Cutting

NATURE REVIEWS GENETICS (2015)

Article Biochemistry & Molecular Biology

Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl) amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors

Yonghui Wang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2014)

Article Biology

Docking assay of small molecule antivirals to p7 of HCV

Leon Bichmann et al.

COMPUTATIONAL BIOLOGY AND CHEMISTRY (2014)

Article Cell Biology

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression

Guido Veit et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Pharmacology & Pharmacy

Rescuing Mutant CFTR: A Multi-task Approach to a Better Outcome in Treating Cystic Fibrosis

Margarida D. Amaral et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

Article Biochemistry & Molecular Biology

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

Tsukasa Okiyoneda et al.

NATURE CHEMICAL BIOLOGY (2013)

Article Multidisciplinary Sciences

Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle

Kang-Yang Jih et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Substantial improvements in large-scale redocking and screening using the novel HYDE scoring function

Nadine Schneider et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2012)

Article Neurosciences

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia

Paolo Scudieri et al.

JOURNAL OF PHYSIOLOGY-LONDON (2012)

Review Biochemistry & Molecular Biology

CFTR: folding, misfolding and correcting the ΔF508 conformational defect

Gergely L. Lukacs et al.

TRENDS IN MOLECULAR MEDICINE (2012)

Review Chemistry, Multidisciplinary

Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis

Zhi-wei Cai et al.

ACTA PHARMACOLOGICA SINICA (2011)

Article Multidisciplinary Sciences

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

Fredrick Van Goor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Multidisciplinary Sciences

Adapting proteostasis for disease intervention

William E. Balch et al.

SCIENCE (2008)

Article Biochemistry & Molecular Biology

Domain interdependence in the biosynthetic assembly of CFTR

Liying Cui et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Chemistry, Medicinal

Molecular properties that influence the oral bioavailability of drug candidates

DF Veber et al.

JOURNAL OF MEDICINAL CHEMISTRY (2002)