期刊
PHARMACEUTICALS
卷 15, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ph15050535
关键词
anticancer activity; cytotoxicity; Hymenocardia acida; nanoencapsulation; nanoparticle; plant extract; PLGA
资金
- Fundacao para a Ciencia e a Tecnologia (FCT) from CBIOS - Research Center for Biosciences and Health Technologies [UIDB/04326/2020, UIDP/04326/2020]
- Research Unit Institute for Bioengineering and Biosciences-iBB [UIDB/04565/2020, UIDP/04565/2020]
- LAQV/REQUIMTE [UIDB/50006/2020]
- Associate Laboratory Institute for Health and Bioeconomy-i4HB [LA/P/0140/2020]
- FCT, Portugal [2020.08839.BD]
- PADDIC - ALIES
- Fundação para a Ciência e a Tecnologia [2020.08839.BD, UIDP/04326/2020] Funding Source: FCT
This study evaluated the anticancer properties of African shrub H. acida and delivered it using PLGA nanoparticles. The results showed that H. acida exhibited notable cytotoxic activity, but the activity was reduced upon encapsulation in nanoparticles.
Hymenocardia acida (H. acida) is an African well-known shrub recognized for numerous medicinal properties, including its cancer management potential. The advent of nanotechnology in delivering bioactive medicinal plant extract with poor solubility has improved the drug delivery system, for a better therapeutic value of several drugs from natural origins. This study aimed to evaluate the anticancer properties of H. acida using human lung (H460), breast (MCF-7), and colon (HCT 116) cancer cell lines as well as the production, characterization, and cytotoxicity study of H. acida loaded into PLGA nanoparticles. Benchtop models of Saccharomyces cerevisiae and Raniceps ranninus were used for preliminary toxicity evaluation. Notable cytotoxic activity in benchtop models and human cancer cell lines was observed for H. acida crude extract. The PLGA nanoparticles loading H. acida had a size of about 200 nm and an association efficiency of above 60%, making them suitable to be delivered by different routes. The outcomes from this research showed that H. acida has anticancer activity as claimed from an ethnomedical point of view; however, a loss in activity was noted upon encapsulation, due to the sustained release of the drug.
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