Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids

Article Neurosciences

Nutraceutical Molecules Slow Down Retinal Degeneration, in Tvrm4 Mice a Model of Retinitis Pigmentosa, by Genetic Modulation of Anti-oxidant Pathway

Ilaria Piano et al.

Summary: Treatment with naringenin and quercetin can alleviate retinal degeneration by preserving photoreceptor functionality and increasing antioxidant and anti-apoptotic pathways.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Biochemistry & Molecular Biology

The protective, rescue and therapeutic potential of multi-target iron-chelators for retinitis pigmentosa

Bin Lin et al.

Summary: Retinitis pigmentosa (RP) is a group of inherited diseases causing night vision loss and eventual blindness, with no effective therapy currently available. Targeted gene therapy may only benefit a small portion of RP patients due to the disease's heterogeneity. Non-gene-specific therapeutics could have significant effects on the majority of RP patients. Iron-chelating compounds like VK28, M30, and VAR10303 show potential as therapeutic agents for RP by targeting multiple pathological features.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects

Ana Garcia-Aguilar et al.

Summary: Polyphenols are secondary metabolites of plants that regulate various biological processes, offering protection against inflammation, oxidative stress, and related injuries. They promote autophagy, enhance mitochondrial function and antioxidant defenses, reduce oxidative stress, and decrease cell apoptosis, potentially explaining their health-promoting properties.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Oxidative Stress, Plant Natural Antioxidants, and Obesity

Israel Perez-Torres et al.

Summary: Oxidative stress plays a crucial role in the pathophysiology of obesity, and various antioxidant compounds found in plants have therapeutic potential for treating obesity. However, further controlled clinical trials are needed to better understand the effects of these compounds.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Geriatrics & Gerontology

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer's Disease

Afzal Misrani et al.

Summary: Mitochondria play a pivotal role in cell viability, with changes in morphology and dysfunction being closely linked to the pathogenesis of diseases like Alzheimer's. Restoring mitochondrial function can potentially delay the progression of Alzheimer's disease.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Review Biochemistry & Molecular Biology

Beyond Antioxidant Effects: Nature-Based Templates Unveil New Strategies for Neurodegenerative Diseases

Andrea Bacci et al.

Summary: The pathogenesis of neurodegenerative diseases is complex, making drug development challenging. Redox reactions play a crucial role in maintaining neuronal microenvironment homeostasis. A shift in drug discovery methods towards innovative polypharmacology approaches is gradually occurring in order to tackle the relentless progress of these diseases.

ANTIOXIDANTS (2021)

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Review Biology

Molecules and Mechanisms to Overcome Oxidative Stress Inducing Cardiovascular Disease in Cancer Patients

Francesco Sabbatino et al.

Summary: Reactive oxygen species (ROS) play a dual role in cell signaling, with both beneficial and detrimental effects. In pathological conditions, ROS production exceeds the antioxidative detoxification capacity of cells, leading to cellular damage and death. Strategies to counteract oxidative stress in cardiovascular disease and oncological treatments are discussed in this review.

LIFE-BASEL (2021)

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Review Biochemistry & Molecular Biology

Role of Oral Antioxidant Supplementation in the Current Management of Diabetic Retinopathy

Enrique Antonio Alfonso-Munoz et al.

Summary: The review suggests that antioxidant supplementation in adult Type 1 and Type 2 diabetes mellitus patients without retinopathy or mild-to-moderate nonproliferative DR and without diabetic macular edema has a IIB level of recommendation as a complementary therapy with standard medical care.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals

Da-Young Lee et al.

Summary: Colorectal cancer has a high prevalence in patients with inflammatory bowel disease, and oxidative stress is known to be one of the causes of inflammatory diseases and malignant disorders. The Nrf2/KEAP1 pathway is believed to protect cells from oxidative stress and inflammation. Phytochemicals may play a role in preventing or inhibiting colorectal cancer progression.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Nutraceutical Supplementation Ameliorates Visual Function, Retinal Degeneration, and Redox Status in rd10 Mice

Lorena Olivares-Gonzalez et al.

Summary: In this study, the nutraceutical mixture with antioxidant properties (NUT) was found to delay retinal degeneration in rd10 mice, a model of RP. NUT treatment improved redox status, reduced inflammation, and preserved retinal functionality and morphology in early stages of RP. This formulation could potentially serve as a neuroprotective approach for patients with RP in the future.

ANTIOXIDANTS (2021)

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Article Medicine, Research & Experimental

Oral N-acetylcysteine improves cone function in retinitis pigmentosa patients in phase I trial

Peter A. Campochiaro et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Biochemistry & Molecular Biology

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Dominic S. A. Simpson et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration

Patrycja Michalska et al.

ANTIOXIDANTS (2020)

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Review Neurosciences

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

Tiantian Guo et al.

MOLECULAR NEURODEGENERATION (2020)

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Article Chemistry, Medicinal

Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities

Xiaoying Jiang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Biochemical Research Methods

Detecting Oxidative Stress Biomarkers in Neurodegenerative Disease Models and Patients

Yulia Sidorova et al.

METHODS AND PROTOCOLS (2020)

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Article Biochemistry & Molecular Biology

Reversing ROS-mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2-ARE signaling pathway

Juan Yao et al.

BIOFACTORS (2019)

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Article Neurosciences

A Nutraceutical Strategy to Slowing Down the Progression of Cone Death in an Animal Model of Retinitis Pigmentosa

Ilaria Piano et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Chemistry, Medicinal

Multi-targeted ChEI-copper chelating molecules as neuroprotective agents

Simona Sestito et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Chemistry, Medicinal

Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease?

Simona Sestito et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Review Neurosciences

Iron, Ferritin, Hereditary Ferritinopathy, and Neurodegeneration

Barry B. Muhoberac et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Chemistry, Medicinal

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease

Asha Hiremathad et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

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Review Endocrinology & Metabolism

Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

Karolina Pierzynowska et al.

METABOLIC BRAIN DISEASE (2018)

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Article Ophthalmology

Protective effect of sulforaphane against retinal degeneration in the Pde6rd10 mouse model of retinitis pigmentosa

Kai Kang et al.

CURRENT EYE RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Activation of apoptosis signalling pathways by reactive oxygen species

Maureen Redza-Dutordoir et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

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Article Chemistry, Medicinal

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease

Federica Prati et al.

CHEMMEDCHEM (2016)

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Review Food Science & Technology

Inhibitory mechanism against oxidative stress of caffeic acid

Farhan Ahmed Khan et al.

JOURNAL OF FOOD AND DRUG ANALYSIS (2016)

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Article Clinical Neurology

Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial

D. Angus et al.

LANCET NEUROLOGY (2015)

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Review Medicine, Research & Experimental

The Role of Oxidative Stress in Neurodegenerative Diseases

Geon Ha Kim et al.

EXPERIMENTAL NEUROBIOLOGY (2015)

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Article Biochemistry & Molecular Biology

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease

Lana Kupershmidt et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

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Letter Neurosciences

Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells

Wen-Yong Huang et al.

CNS NEUROSCIENCE & THERAPEUTICS (2012)

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Article Multidisciplinary Sciences

Safranal, a Saffron Constituent, Attenuates Retinal Degeneration in P23H Rats

Laura Fernandez-Sanchez et al.

PLOS ONE (2012)

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Article Chemistry, Inorganic & Nuclear

Redox active metal-induced oxidative stress in biological systems

Klaudia Jomova et al.

TRANSITION METAL CHEMISTRY (2012)

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Article Cell Biology

N-Acetylcysteine Promotes Long-Term Survival of Cones in a Model of Retinitis Pigmentosa

Sun Young Lee et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2011)

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Article Biochemistry & Molecular Biology

Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration

Brian C. Oveson et al.

JOURNAL OF NEUROCHEMISTRY (2011)

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Article Pharmacology & Pharmacy

Chronic Inflammation and Oxidative Stress as a Major Cause of Age-Related Diseases and Cancer

Nemat Khansari et al.

RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY (2009)

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Article Cell Biology

Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa

Keiichi Komeima et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2007)

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Article Biochemistry & Molecular Biology

Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease

Yael Avramovich-Tirosh et al.

JOURNAL OF NEUROCHEMISTRY (2007)

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Article Cell Biology

Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa

JK Shen et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2005)

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Article Cell Biology

Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases

MBH Youdim et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2005)

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Review Pharmacology & Pharmacy

Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid

H Moini et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2002)

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Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids

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