期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 12, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jpm12040636
关键词
brachial-ankle pulse wave velocity (baPWV); cardiovascular (CV) biomarkers; hemodialysis
资金
- Ministry of Science and Technology, Taiwan [MOST 107-2314-B-037-021-MY2, MOST 109-2314-B-037-088]
- Kaohsiung Medical University Hospital, Taiwan [KMUH102-2R09, KMUH104-4R09, KMUH105-5R16, KMUH109-9R16, KMUH110-0M12, KMUH110-0M13, 110003-3]
- Kaohsiung Medical University [KMU-DK(B)110003, KMU-Q108024, NPUST-KMU-111-P001, NHRIKMU-111-I001-3]
This study investigated the relationship between circulating cardiovascular biomarkers and brachial-ankle pulse wave velocity (baPWV) in hemodialysis patients. The results showed that high-sensitivity troponin-T (hsTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), Galectin-3, and Cathepsin D were significantly correlated with baPWV.
Brachial-ankle pulse wave velocity (baPWV) and cardiovascular (CV) biomarkers are correlated with clinical cardiovascular diseases (CVDs) in patients with kidney disease. However, limited studies evaluated the relationship between baPWV and CV biomarkers in hemodialysis patients. This study investigated the relationship between circulating CV biomarkers and baPWV in patients on hemodialysis. Hemodialysis patients were enrolled between August 2016 and January 2017 for the measurement of baPWV, traditional CV biomarkers, including high-sensitivity troponin-T (hsTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), and novel CV biomarkers, including Galectin-3, Cathepsin D, placental growth factor, Endocan-1, and Fetuin-A. The independent association was assessed by multivariate-adjusted linear regression analysis to control for potential confounders. The final analysis included 176 patients (95 men and 81 women) with a mean age of 60 +/- 11 y old. After adjusting for age and sex, hsTnT (p < 0.01), NT-proBNP (p = 0.01), Galectin-3 (p = 0.03), and Cathepsin D (p < 0.01) were significantly directly correlated with baPWV. The direct correlation with baPWV existed in multivariable linear regression models with a beta of 0.1 for hsTnT and 0.1 for Cathepsin D. The direct relationship between baPWV and CV biomarkers, particularly with hsTnT and Cathepsin D, may be helpful for risk stratification of hemodialysis patients.
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