Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization

Based on the study of recent scientific literature devoted to neovascularization and angiogenesis in malignant neoplasms, it was concluded that there are many publications on each of the problems of tumor angiogenesis and vascularization. The formation of blood vessels in a tumor and certain aspects of the prognostic value of the severity of vascularization in almost all forms of cancer are considered. Special attention is paid to the peculiarities of angiogenesis in tumors of the female reproductive system. A large number of vessels in the tumor often indicates a poor prognosis. The influence of various factors on the initiation of angiogenesis and the process itself, as well as the possibility of suppressing such signals to slow down the formation of blood vessels and thus the development of the tumor are widely studied. The results of pharmacological suppression of tumor vessel formation demonstrate a good clinical outcome but one accompanied by a large number of severe adverse side effects. Such a significant amount of studies on each of the problems of tumor vascularization indicates the increasing importance of this area of oncology. At the same time, only a very small number of works are devoted to the study of the differences in angiogenesis and number of vessels between different parts of the tumor, as well as between the primary tumor node and its metastases. The refinement of the results is still to be done. It was noted that the expression of proangiogenic factors in metastases is usually higher than in the source of metastasis, and the expression in lymphogenous metastases is higher than in hematogenous ones.

Automated summary

Based on recent scientific literature on neovascularization and angiogenesis in malignant neoplasms, it is concluded that there are numerous studies on tumor angiogenesis and vascularization. The formation of blood vessels in tumors and the prognostic value of vascularization severity in almost all cancer forms are discussed. Angiogenesis in tumors of the female reproductive system is given special attention. A high number of vessels in tumors often indicates a poor prognosis. Extensive research is being conducted on the influence of various factors on angiogenesis initiation and the possibility of suppressing angiogenesis signals to slow down tumor growth. Pharmacological suppression of tumor vessel formation shows promising clinical outcomes but is accompanied by severe side effects. The significant amount of research on tumor vascularization highlights the increasing importance of this area in oncology. However, there is still limited research on the differences in angiogenesis and vessel number between different parts of tumors, as well as between primary tumor nodes and metastases. Further refinement of the results is needed. It has been noted that the expression of proangiogenic factors is usually higher in metastases than in the primary source, and higher in lymphogenous metastases compared to hematogenous ones.