期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 12, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/jpm12050682
关键词
anorexia nervosa; weight restoration treatment; post-meal
资金
- Axel Muusfeldts Fond
- Dagmar Marshalls Fond
- Direktor Emil C. Hert og Hustru Inger Hertz Fond
- Jascha Fonden
- Psychiatric Center Ballerup
- Psychiatry section of the Capitol Region of Denmark
This study observed 49 patients with anorexia nervosa during a 8-week inpatient treatment, using self-rating measures to assess depressiveness and eating disorder psychopathology. The study found that inpatient treatment was associated with a reduction in depressiveness, which correlated with an improvement in eating disorder pathology but not with weight gain.
Objective: Anorexia nervosa (AN) is a severe mental disorder frequently associated with high scores of depressiveness. We examined the short-term effects of inpatient treatment on depressiveness and eating disorder (ED) psychopathology using the self-rating Major Depression Inventory (MDI) and Eating Disorder Examination questionnaire (EDEq) for patients with AN. Material: Forty-nine patients with AN, all part of the PROspective Longitudinal all-comer inclusion study on EDs (PROLED), were observed over eight weeks with baseline psychometric measures, EDE-q at baseline and endpoint, and weekly MDI self-scoring. Methods: Apart from the weekly Body Mass Index (BMI) measurements, patients were assessed at baseline using the Eating Disorder Inventory (EDI) and the Symptom Check List 92 (SCL-92). Results: Inpatient treatment reduced MDI consistently over 8 weeks (Wilks Lambda = 0.59, F = 4.1, p < 0.01) and this reduction in MDI was positively correlated with a reduction in EDEq (r = 0.44; p < 0.01) during inpatient treatment. Baseline medication did not predict changes in MDI during the inpatient treatment. BMI increased from 14.9 (week 1) to 17.2 (week 8). Conclusions: Inpatient treatment of AN is associated with a reduction in depressiveness. This improvement in depressiveness scores correlates with an improvement in ED psychopathology but not with weight gain.
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