期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 12, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/jpm12050798
关键词
Cushing's disease; hypercortisolism; transsphenoidal surgery; remission; predictors
资金
- Ministry of Science and Higher Education of the Russian Federation [075-15-2022-301]
This study aimed to find a combination of predictors to forecast Cushing's disease (CD) remission after transsphenoidal endoscopic surgery (TSS). The results showed that adenoma size, high-dose dexamethasone suppression test (HDDST) serum cortisol suppression rate, and morning serum cortisol level 24 hours after surgery were predictors of CD remission one year after TSS.
Persistent and recurrent hypercortisolism after transsphenoidal endoscopic surgery (TSS) is considered to be an urgent issue prompting the search for Cushing's disease (CD) remission predictors. The goal was to find a combination of predictors that can forecast the remission of CD after TSS. A total of 101 patients with CD who had undergone TSS were included. One year after surgery, CD remission status was evaluated. Preoperative pituitary magnetic resonance imaging (MRI) data, preoperative results of a high-dose dexamethasone suppression test (HDDST) and morning serum cortisol level collected 24 h after TSS (24 h MSeC) were compared in patients with and without remission of hypercortisolism. Remission one year after TSS was confirmed in 63 patients. CD remission predictors one year after TSS were: adenoma size >= 3 mm in the absence of invasive growth and the suppression of serum cortisol >= 74% in the HDDST, 24 h MSeC <= 388 nmol/L. A total of 38 patients had three favorable values of detected predictors; all of them had CD remission one year after TSS. With long-term follow-up, 36 of them remained in remission. Patients who had no one favorable predictor had no remission of hypercortisolism one year after TSS. Our data confirmed the prospects of using a combination of selected predictors to forecast CD remission after TSS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据