Cardiac Allograft Rejection Induces Changes in Nucleocytoplasmic Transport: RANGAP1 as a Potential Non-Invasive Biomarker

Article Health Care Sciences & Services

Electron Microscopy Reveals Evidence of Perinuclear Clustering of Mitochondria in Cardiac Biopsy-Proven Allograft Rejection

Estefania Tarazon et al.

Summary: This study focuses on analyzing new ultrastructural findings in cardiac biopsy rejection through the observation of perinuclear clustering of mitochondria, which could complement and improve the diagnosis of rejection.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Article Immunology

Plasma Levels of SERCA2a as a Noninvasive Biomarker of Primary Graft Dysfunction After Heart Transplantation

Silvia Lozano-Edo et al.

Summary: This study suggests that assessing plasma levels of SERCA2a may improve risk prediction for primary graft dysfunction (PGD) and could serve as a new noninvasive biomarker in patients undergoing heart transplantation (HT).

TRANSPLANTATION (2022)

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Article Cardiac & Cardiovascular Systems

Cell-Free DNA to Detect Heart Allograft Acute Rejection

Sean Agbor-Enoh et al.

Summary: This study validated the use of %ddcfDNA as a sensitive blood biomarker for detecting acute rejection in cardiac transplant recipients. It showed excellent performance characteristics in early detection and could potentially reduce the need for invasive endomyocardial biopsies.

CIRCULATION (2021)

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Article Immunology

Alterations in the Nucleocytoplasmic Transport in Heart Transplant Rejection

Silvia Lozano-Edo et al.

Summary: This study aimed to evaluate the relationship between serum levels of nucleocytoplasmic transport-related molecules and cellular rejection (CR) in heart transplantation (HT) recipients. The results showed that patients with CR had higher levels of IMP5, Nup153, and RanGAP1 in their serum, with significant differences compared to the non-CR group.

TRANSPLANTATION PROCEEDINGS (2021)

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Article Health Care Sciences & Services

Value of SERCA2a as a Biomarker for the Identification of Patients with Heart Failure Requiring Circulatory Support

Meryem Ezzitouny et al.

Summary: This study suggests that patients with advanced HF requiring mechanical circulatory support have significantly lower levels of SERCA2a compared to stable patients without a need for MCS prior to heart transplantation. Larger studies are needed to further confirm and validate these findings.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Biology

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1

Yujiao He et al.

Summary: The study reveals that PKC-theta phosphorylates RanGAP1 to facilitate the assembly and nuclear import of the RanBP2 subcomplex, shedding light on a new link between TCR signaling and NPC assembly. This phosphorylation-dependent sumoylation of RanGAP1 increases its binding affinity for Ubc9, leading to the formation of the RanBP2 subcomplex.

ELIFE (2021)

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Article Cardiac & Cardiovascular Systems

Circulating miR-181a-5p as a new biomarker for acute cellular rejection in heart transplantation

Ignacio Constanso-Conde et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

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Article Cardiac & Cardiovascular Systems

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report-2019; focus theme: Donor and recipient size match

Kiran K. Khush et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

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Article Multidisciplinary Sciences

Circulating Sphingosine-1-Phosphate as A Non-Invasive Biomarker of Heart Transplant Rejection

Estefania Tarazon et al.

SCIENTIFIC REPORTS (2019)

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Article Cardiac & Cardiovascular Systems

MicroRNA signatures in cardiac biopsies and detection of allograft rejection

Andrea Di Francesco et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2018)

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Article Cardiac & Cardiovascular Systems

SERCA2a: A potential non-invasive biomarker of cardiac allograft rejection

Estefania Tarazon et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2017)

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Article Multidisciplinary Sciences

The Ran GTPase-Activating Protein (RanGAP1) Is Critically Involved in Smooth Muscle Cell Differentiation, Proliferation and Migration following Vascular Injury: Implications for Neointima Formation and Restenosis

Marc Vorpahl et al.

PLOS ONE (2014)

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Review Transplantation

Do established biomarkers such as B-type natriuretic peptide and troponin predict rejection?

Douglas A. Hill et al.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2013)

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Article Cardiac & Cardiovascular Systems

The Registry of the International Society for Heart and Lung Transplantation: 29th Official Adult Heart Transplant Report-2012

Josef Stehlik et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2012)

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Article Multidisciplinary Sciences

Heart Failure Induces Significant Changes in Nuclear Pore Complex of Human Cardiomyocytes

Estefania Tarazon et al.

PLOS ONE (2012)

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Article Cardiac & Cardiovascular Systems

Influence of heart failure on nucleocytoplasmic transport in human cardiomyocytes

Raquel Cortes et al.

CARDIOVASCULAR RESEARCH (2010)

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Article Cardiac & Cardiovascular Systems

Adverse Event Rates in Congenital Cardiac Catheterization - A Multi-Center Experience

Lisa Bergersen et al.

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS (2010)

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Article Cardiac & Cardiovascular Systems

Usefulness of Serial Monitoring of B-Type Natriuretic Peptide for the Detection of Acute Rejection After Heart Transplantation

Iris P. Garrido et al.

AMERICAN JOURNAL OF CARDIOLOGY (2009)

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Article Surgery

What is the best biomarker for diagnosis of rejection in heart transplantation?

L. Martinez-Dolz et al.

CLINICAL TRANSPLANTATION (2009)

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Article Cardiac & Cardiovascular Systems

The Change in B-Type Natriuretic Peptide Levels Over Time Predicts Significant Rejection in Cardiac Transplant Recipients

Michelle M. Kittleson et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2009)

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Article Cardiac & Cardiovascular Systems

Cytokines, interstitial collagen and ventricular remodelling in dilated cardiomyopathy

Pekka Timonen et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2008)

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Review Cell Biology

Spatial and temporal coordination of mitosis by Ran GTPase

Paul R. Clarke et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

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Review Biochemistry & Molecular Biology

Nucleocytoplasmic transport of proteins

A. V. Sorokin et al.

BIOCHEMISTRY-MOSCOW (2007)

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Article Cardiac & Cardiovascular Systems

Is brain natriuretic peptide clinically useful after cardiac transplantation?

Steven M. Shaw et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2006)

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Article Cardiac & Cardiovascular Systems

The cumulative effect of acute rejection on development of cardiac allograft vasculopathy

SC Stoica et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2006)

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Article Cardiac & Cardiovascular Systems

Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection

S Stewart et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2005)

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Review Cell Biology

Mechanisms of receptor-mediated nuclear import and nuclear export

LF Pemberton et al.

TRAFFIC (2005)

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Article Cardiac & Cardiovascular Systems

Brain natriuretic peptide predicts serious cardiac allograft rejection independent of hemodynamic measurements

AH Wu et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2005)

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Cardiac Allograft Rejection Induces Changes in Nucleocytoplasmic Transport: RANGAP1 as a Potential Non-Invasive Biomarker

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