期刊
ISCIENCE
卷 25, 期 7, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2022.104475
关键词
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资金
- Brown University [CC13210.1091]
- Environmental Protection Agency [RD-834557501-0]
- National Science Foundation [CMMI-1057906]
- Center for Biological and Environmental Nanotechnology (NSF) [EEC-0647452]
This study characterized the dissolution process and associated biological activity of silver nanoparticles with different dimensions, shapes, and surface chemistries. A quantitative model was developed to relate material structure to silver dissolution and microbial toxicity. The results showed that shape had the most profound influence on antibacterial activity, while surface coatings had the least impact.
Silver nanomaterials have potent antibacterial properties that are the foundation for their wide commercial use as well as for concerns about their unintended environmental impact. The nanoparticles themselves are relatively biologically inert but they can undergo oxidative dissolution yielding toxic silver ions. A quantitative relationship between silver material structure and dissolution, and thus antimicrobial activity, has yet to be established. Here, this dissolution process and associated biological activity is characterized using uniform nanoparticles with variable dimension, shape, and surface chemistry. From this, a phenomenological model emerges that quantitatively relates material structure to both silver dissolution and microbial toxicity. Shape has the most profound influence on antibacterial activity, and surprisingly, surface coatings the least. These results illustrate how material structure may be optimized for antimicrobial properties and suggest strategies for minimizing silver nanoparticle effects on microbes.
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