期刊
ISCIENCE
卷 25, 期 6, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2022.104431
关键词
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资金
- National Science Fund for Distinguished Young Scholars [82025022]
- National Natural Science Foundation of China [92169204, 82002140, 82171752, 82101861]
- National Key Plan for Scientific Research and Development of China [2021YFC0864500]
- Guangdong Basic and Applied Basic Research Foundation [2021B1515020034, 2021A1515011009]
- Shenzhen Science and Technology Program [RCYX20200714114700046]
- Sci- ence and Technology Innovation Committee of Shenzhen Municipality [JSGG20200207155251653, JSGG20200807171401008, JSGG20210901145200002, KQTD20200909113758004]
- Southern University of Science and Technology
This article explores the structure and function of STS165, a broadly inter-Spike bivalent neutralizing antibody (nAb) against SARS-CoV-2 variants and even SARS-CoV, contributing to further understanding of the working mechanism of nAbs.
The different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have attracted most public concern because they caused wave and wave COVID-19 pandemic. The initial step of viral infection is mediated by the SARS-CoV-2 Spike (S) protein, which mediates the receptor recognition and membrane fusion between virus and host cells. Neutralizing antibodies (nAbs) targeting the S protein of SARS-CoV-2 have become promising candidates for clinical intervention strategy, while multiple studies have shown that different variants have enhanced infectivity and antibody resistance. Here, we explore the structure and function of STS165, a broadly inter-Spike bivalent nAb against SARS-CoV-2 variants and even SARS-CoV, contributing to further understanding of the working mechanism of nAbs.
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