☆ 4.7 Article

Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19

ISCIENCE (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pathology

Coronavirus Disease 2019 (COVID-19) Coronary Vascular Thrombosis Correlation with Neutrophil but Not Endothelial Activation

Justin E. Johnson et al.

Summary: Severe COVID-19 patients showed frequent and extensive thrombosis in the heart along with signs of neutrophil activation within myocardial thrombi. This suggests that alterations in circulating neutrophils may contribute to the increased thrombotic diathesis in the hearts of COVID-19 patients.

AMERICAN JOURNAL OF PATHOLOGY (2022)

添加到收藏夹

Article Allergy

Compartmental immunophenotyping in COVID-19 ARDS: A case series

Andreas Ronit et al.

Summary: In critically ill patients with COVID-19 ARDS, there is a distinct immunological profile in the lungs, characterized by a dominance of immature neutrophils, lymphopenia of CD4 and CD8 T cells, and higher fractions of regulatory T cells and TH17 cells. The lung exhibits a heavily hyperinflammatory environment with upregulation of activation markers on CD4 and CD8 T cells and macrophages, along with high levels of various cytokines such as IL-1RA, IL-6, IL-8, IP-10, and MCP-1.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination

Zhengrong Zhang et al.

Summary: In COVID-19 patients, SARS-CoV-2 infection leads to the presence of heterotypic cell-in-cell structures in lung tissues with lymphocytes inside multinucleate syncytia. The membrane fusion induced by the spike glycoprotein is controlled by a bi-arginine motif, and candidate anti-viral drugs can efficiently inhibit this process. This study provides insights into the molecular and cellular mechanisms of SARS-CoV-2 pathogenesis and identifies potential novel targets for COVID-19 therapy.

CELL DEATH AND DIFFERENTIATION (2021)

添加到收藏夹

Article Immunology

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

Laura Bergamaschi et al.

Summary: The kinetics of immune changes in COVID-19 across different severity groups show that early bystander CD8(+) T cell immune response is prominent in asymptomatic or mild diseases, while severe cases have persistent cellular abnormalities and immune defects, which may increase clinical risks.

IMMUNITY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

Luca Braga et al.

Summary: COVID-19 patients' lungs contain infected pneumocytes with abnormal morphology and frequent multinucleation, leading to the formation of syncytia driven by the activation of the SARS-CoV-2 spike protein. The antihelminthic drug niclosamide has shown to effectively inhibit cell fusion, potentially providing a new therapeutic approach for COVID-19 disease pathogenesis.

NATURE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Single-cell multi-omics analysis of the immune response in COVID-19

Emily Stephenson et al.

Summary: Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.

NATURE MEDICINE (2021)

添加到收藏夹

Article Hematology

COVID-19-associated coagulopathy and antithrombotic agents-lessons after 1 year

Jenneke Leentjens et al.

Summary: There is a high incidence of venous thromboembolism in COVID-19 patients, with treatment strategies varying based on patient severity and treatment stage. High-quality evidence on antithrombotic therapy in COVID-19 patients is emerging, with ongoing studies expected to provide further guidance for clinicians.

LANCET HAEMATOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

Ewan C. Goligher et al.

Summary: In critically ill patients with Covid-19, initial therapeutic-dose anticoagulation did not result in improved survival rates or fewer days requiring cardiovascular or respiratory organ support compared to usual-care pharmacologic thromboprophylaxis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow

Behnood Bikdeli et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

添加到收藏夹

Article Hematology

Marked factor V activity elevation in severeCOVID-19 is associated with venous thromboembolism

Jonathan A. Stefely et al.

AMERICAN JOURNAL OF HEMATOLOGY (2020)

添加到收藏夹

Review Immunology

Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies

Ting Zhou et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Article Immunology

Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

Coraline Radermecker et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Article Immunology

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

Flavio Protasio Veras et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Article Medicine, General & Internal

Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology

Rossana Bussani et al.

EBIOMEDICINE (2020)

添加到收藏夹

Article Cell Biology

Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study

Dami A. Collier et al.

CELL REPORTS MEDICINE (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Daehwan Kim et al.

NATURE BIOTECHNOLOGY (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Vireo: Bayesian demultiplexing of pooled single-cell RNA-seq data without genotype reference

Yuanhua Huang et al.

GENOME BIOLOGY (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

EmptyDrops: distinguishing cells from empty droplets in droplet-based single-cell RNA sequencing data

Aaron T. L. Lun et al.

GENOME BIOLOGY (2019)

添加到收藏夹

Article Hematology

Factor V Leiden

Elizabeth M. Van Cott et al.

AMERICAN JOURNAL OF HEMATOLOGY (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Pharmacology of anticoagulants used in the treatment of venous thromboembolism

Edith A. Nutescu et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Coagulation factor VA2440G causes east Texas bleeding disorder via TFPIα

Lisa M. Vincent et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Characterization of coagulation factor synthesis in nine human primary cell types

Monireh Dashty et al.

SCIENTIFIC REPORTS (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors

Steven T. Olson et al.

BIOCHIMIE (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Warfarin and the vitamin K-dependent γ-carboxylation system

R Wallin et al.

TRENDS IN MOLECULAR MEDICINE (2004)

添加到收藏夹

Article Critical Care Medicine

Effect of factor V Leiden polymorphism in severe sepsis and on treatment with recombinant human activated protein C

SB Yan et al.

CRITICAL CARE MEDICINE (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.